Snail is the master gene of epithelial–mesenchymal transition (EMT), a program of cell development characterized by loss of cell adhesion, repression of E-cadherin and increased cell mobility. EMT has also been implicated in two of the most important processes responsible for cancer-related mortality: formation of metastasis and acquisition of therapeutic resistance. The molecular mechanisms that govern the different roles of Snail in tumor progression are poorly understood, but recent works have shown that Snail is an anti-apoptotic factor necessary for the survival of migrating cells. Growing evidences indicate that PARP-1 is involved in controlling Snail expression and, taking in consideration Snail cytoprotective role, we assume that PARP-1 contribution to Snail expression modulates the resistance to apoptosis of some types of cancer cells. In this study we investigate whether PARP-1 is involved in the regulation of Snail level upon induction of DNA damage by doxorubicin.
PARP-1 controls Snail expression in epithelial cancer cells exposed to doxorubicin / Mariano, Germano; Zampieri, Michele; Ciccarone, Fabio; Guastafierro, Tiziana; Calabrese, Roberta; Valentini, Elisabetta; Caiafa, Paola; Reale, Anna. - STAMPA. - (2013), pp. 132-132. (Intervento presentato al convegno PARP 2013 19th International Conference on ADP-ribosylation tenutosi a Quebec City, Canada nel September 6-9, 2013).
PARP-1 controls Snail expression in epithelial cancer cells exposed to doxorubicin
MARIANO, GERMANO;ZAMPIERI, Michele;CICCARONE, FABIO;GUASTAFIERRO, Tiziana;CALABRESE, ROBERTA;VALENTINI, ELISABETTA;CAIAFA, Paola;REALE, Anna
2013
Abstract
Snail is the master gene of epithelial–mesenchymal transition (EMT), a program of cell development characterized by loss of cell adhesion, repression of E-cadherin and increased cell mobility. EMT has also been implicated in two of the most important processes responsible for cancer-related mortality: formation of metastasis and acquisition of therapeutic resistance. The molecular mechanisms that govern the different roles of Snail in tumor progression are poorly understood, but recent works have shown that Snail is an anti-apoptotic factor necessary for the survival of migrating cells. Growing evidences indicate that PARP-1 is involved in controlling Snail expression and, taking in consideration Snail cytoprotective role, we assume that PARP-1 contribution to Snail expression modulates the resistance to apoptosis of some types of cancer cells. In this study we investigate whether PARP-1 is involved in the regulation of Snail level upon induction of DNA damage by doxorubicin.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
