Safe trafficking of iron across the cell membrane is a delicate process that requires specific protein carriers. While many proteins involved in iron uptake by cells are known, only one cellular iron export protein has been identified in mammals: ferroportin (SLC40A1). Ceruloplasmin is a multicopper enzyme endowed with ferroxidase activity that is found as a soluble isoform in plasma or as a membrane-associated isoform in specific cell types. According to the currently accepted view, ferrous iron transported out of the cell by ferroportin would be safely oxidized by ceruloplasmin to facilitate loading on transferrin. Therefore, the ceruloplasmin-ferroportin system represents the main pathway for cellular iron egress and it is responsible for physiological regulation of cellular iron levels. The most recent findings regarding the structural and functional features of ceruloplasmin and ferroportin and their relationship will be described in this review.

Ceruloplasmin-ferroportin system of iron traffic in vertebrates / Musci, G; Polticelli, F; BONACCORSI DI PATTI, Maria Carmela. - In: WORLD JOURNAL OF BIOLOGICAL CHEMISTRY. - ISSN 1949-8454. - STAMPA. - 5:(2014), pp. 204-215. [10.4331/wjbc.v5.i2.204]

Ceruloplasmin-ferroportin system of iron traffic in vertebrates

BONACCORSI DI PATTI, Maria Carmela
2014

Abstract

Safe trafficking of iron across the cell membrane is a delicate process that requires specific protein carriers. While many proteins involved in iron uptake by cells are known, only one cellular iron export protein has been identified in mammals: ferroportin (SLC40A1). Ceruloplasmin is a multicopper enzyme endowed with ferroxidase activity that is found as a soluble isoform in plasma or as a membrane-associated isoform in specific cell types. According to the currently accepted view, ferrous iron transported out of the cell by ferroportin would be safely oxidized by ceruloplasmin to facilitate loading on transferrin. Therefore, the ceruloplasmin-ferroportin system represents the main pathway for cellular iron egress and it is responsible for physiological regulation of cellular iron levels. The most recent findings regarding the structural and functional features of ceruloplasmin and ferroportin and their relationship will be described in this review.
2014
ceruloplasmin; ferroportin; iron
01 Pubblicazione su rivista::01a Articolo in rivista
Ceruloplasmin-ferroportin system of iron traffic in vertebrates / Musci, G; Polticelli, F; BONACCORSI DI PATTI, Maria Carmela. - In: WORLD JOURNAL OF BIOLOGICAL CHEMISTRY. - ISSN 1949-8454. - STAMPA. - 5:(2014), pp. 204-215. [10.4331/wjbc.v5.i2.204]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/559874
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