In the present study, we tested the hypothesis that oxidative stress could be implicated in myocardial damage during the acute phase of pneumonia. NOX2 activation, the catalytic subunit of NADPH oxidase, and high-sensitivity cardiac troponin T (hs-cTnT) elevation have been analyzed in two hundred forty-eight consecutive patients hospitalized for community-acquired pneumonia. Serum NOX2-derived peptide (sNOX2-dp), a marker of NOX2 activation, and 8-isoprostaglandin F2 alpha (8-iso-PGF2 alpha), a marker of oxidative stress, were measured upon admission; serum hs-cTnT and ECG were measured every 12 and 24 h, respectively. One hundred thirty-five patients (54%) showed elevated serum levels of hs-cTnT (> 0.014 mu g/L). A logistic regression analysis showed sNOX2-dp (p < 0.001), Pneumonia Severity Index score (p < 0.001), renal failure (p = 0.024), and ejection fraction (p < 0.001) as independent predictors of elevated serum levels of hs-cTnT. Serum sNOX2-dp was linearly correlated with hs-cTnT (Rs = 0.538; p < 0.001) and 8-iso-PGF2 alpha (Rs = 0.354; p < 0.001). The study provides the first evidence of a significant association between serum cardiac Troponin T elevation and NOX2 upregulation in patients with pneumonia. This finding raises the hypothesis that NOX2-derived oxidative stress may be implicated in myocardial injury and that its inhibition could be a novel therapeutic strategy to limit it.

Is NOX2 upregulation implicated in myocardial injury in patients with pneumonia? / Cangemi, Roberto; Calvieri, Camilla; Bucci, Tommaso; Carnevale, Roberto; Marco, Casciaro; Elisabetta, Rossi; Calabrese, CINZIA MYRIAM; Taliani, Gloria; Grieco, Stefania; Falcone, Marco; Palange, Paolo; Bertazzoni, Giuliano; Andrea, Celestini; Pignatelli, Pasquale; Violi, Francesco. - In: ANTIOXIDANTS & REDOX SIGNALING. - ISSN 1523-0864. - STAMPA. - 20:18(2014), pp. 2949-2954. [10.1089/ars.2013.5766]

Is NOX2 upregulation implicated in myocardial injury in patients with pneumonia?

CANGEMI, ROBERTO;CALVIERI, CAMILLA;Tommaso, Bucci;CARNEVALE, Roberto;CALABRESE, CINZIA MYRIAM;TALIANI, Gloria;GRIECO, STEFANIA;FALCONE, MARCO;PALANGE, Paolo;BERTAZZONI, Giuliano;PIGNATELLI, Pasquale;VIOLI, Francesco
2014

Abstract

In the present study, we tested the hypothesis that oxidative stress could be implicated in myocardial damage during the acute phase of pneumonia. NOX2 activation, the catalytic subunit of NADPH oxidase, and high-sensitivity cardiac troponin T (hs-cTnT) elevation have been analyzed in two hundred forty-eight consecutive patients hospitalized for community-acquired pneumonia. Serum NOX2-derived peptide (sNOX2-dp), a marker of NOX2 activation, and 8-isoprostaglandin F2 alpha (8-iso-PGF2 alpha), a marker of oxidative stress, were measured upon admission; serum hs-cTnT and ECG were measured every 12 and 24 h, respectively. One hundred thirty-five patients (54%) showed elevated serum levels of hs-cTnT (> 0.014 mu g/L). A logistic regression analysis showed sNOX2-dp (p < 0.001), Pneumonia Severity Index score (p < 0.001), renal failure (p = 0.024), and ejection fraction (p < 0.001) as independent predictors of elevated serum levels of hs-cTnT. Serum sNOX2-dp was linearly correlated with hs-cTnT (Rs = 0.538; p < 0.001) and 8-iso-PGF2 alpha (Rs = 0.354; p < 0.001). The study provides the first evidence of a significant association between serum cardiac Troponin T elevation and NOX2 upregulation in patients with pneumonia. This finding raises the hypothesis that NOX2-derived oxidative stress may be implicated in myocardial injury and that its inhibition could be a novel therapeutic strategy to limit it.
2014
NOX2; pneumonia; myocardial injury
01 Pubblicazione su rivista::01a Articolo in rivista
Is NOX2 upregulation implicated in myocardial injury in patients with pneumonia? / Cangemi, Roberto; Calvieri, Camilla; Bucci, Tommaso; Carnevale, Roberto; Marco, Casciaro; Elisabetta, Rossi; Calabrese, CINZIA MYRIAM; Taliani, Gloria; Grieco, Stefania; Falcone, Marco; Palange, Paolo; Bertazzoni, Giuliano; Andrea, Celestini; Pignatelli, Pasquale; Violi, Francesco. - In: ANTIOXIDANTS & REDOX SIGNALING. - ISSN 1523-0864. - STAMPA. - 20:18(2014), pp. 2949-2954. [10.1089/ars.2013.5766]
File allegati a questo prodotto
File Dimensione Formato  
Cangemi_Is-NOX2-Upregulation_2014.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 161.02 kB
Formato Adobe PDF
161.02 kB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/559640
Citazioni
  • ???jsp.display-item.citation.pmc??? 10
  • Scopus 25
  • ???jsp.display-item.citation.isi??? 24
social impact