Background: The North American Alzheimer's Disease Neuroimaging Initiative (NA-ADNI) was the first program to develop standardized procedures for Alzheimer's disease (AD) imaging biomarker collection. Objective: We describe the validation of acquisition and processing of structural magnetic resonance imaging (MRI) in different Italian academic AD clinics following NA-ADNI procedures. Methods: 373 patients with subjective memory impairment (n = 12), mild cognitive impairment (n = 92), Alzheimer's dementia (n = 253), and frontotemporal dementia (n = 16) were enrolled in 9 Italian centers. 22 cognitively healthy elderly controls were also included. MRI site qualification and MP-RAGE quality assessment was applied following the NA-ADNI procedures. Indices of validity were: (i) NA-ADNI phantom's signal-to-noise and contrast-to-noise ratio, (ii) proportion of images passing quality control, (iii) comparability of automated intracranial volume (ICV) estimates across scanners, and (iv) known-group validity of manual hippocampal volumetry. Results: Results on Phantom and Volunteers scans showed that I-ADNI acquisition parameters were comparable with those one of the ranked-A ADNI scans. Eighty-seven percent of I-ADNI MPRAGE images were ranked of high quality in comparison of 69% of NA-ADNI. ICV showed homogeneous variances across scanners except for Siemens scanners at 3.0 Tesla (p = 0.039). A significant difference in hippocampal volume was found between AD and controls on 1.5 Tesla scans (p < 0.001), confirming known group validity test. Conclusion: This study has provided standardization of MRI acquisition and imaging marker collection across different Italian clinical units and equipment. This is a mandatory step to the implementation of imaging biomarkers in clinical routine for early and differential diagnosis.

The Italian Alzheimer's Disease Neuroimaging Initiative (I-ADNI): Validation of Structural MR Imaging / E., Cavedo; A., Redolfi; F., Angeloni; Babiloni, Claudio; Lizio, Roberta; L., Chiapparini; M. G., Bruzzone; D., Aquino; U., Sabatini; M., Alesiani; A., Cherubini; E., Salvatore; A., Soricelli; F., Vernieri; F., Scrascia; E., Sinforiani; P., Chiarati; S., Bastianello; P., Montella; D., Corbo; G., Tedeschi; S., Marino; A., Baglieri; S., De Salvo; Carducci, Filippo; C. C., Quattrocchi; M., Cobelli; G. B., Frisoni. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - 40:4(2014), pp. 941-952. [10.3233/jad-132666]

The Italian Alzheimer's Disease Neuroimaging Initiative (I-ADNI): Validation of Structural MR Imaging

BABILONI, CLAUDIO;LIZIO, ROBERTA;CARDUCCI, Filippo;
2014

Abstract

Background: The North American Alzheimer's Disease Neuroimaging Initiative (NA-ADNI) was the first program to develop standardized procedures for Alzheimer's disease (AD) imaging biomarker collection. Objective: We describe the validation of acquisition and processing of structural magnetic resonance imaging (MRI) in different Italian academic AD clinics following NA-ADNI procedures. Methods: 373 patients with subjective memory impairment (n = 12), mild cognitive impairment (n = 92), Alzheimer's dementia (n = 253), and frontotemporal dementia (n = 16) were enrolled in 9 Italian centers. 22 cognitively healthy elderly controls were also included. MRI site qualification and MP-RAGE quality assessment was applied following the NA-ADNI procedures. Indices of validity were: (i) NA-ADNI phantom's signal-to-noise and contrast-to-noise ratio, (ii) proportion of images passing quality control, (iii) comparability of automated intracranial volume (ICV) estimates across scanners, and (iv) known-group validity of manual hippocampal volumetry. Results: Results on Phantom and Volunteers scans showed that I-ADNI acquisition parameters were comparable with those one of the ranked-A ADNI scans. Eighty-seven percent of I-ADNI MPRAGE images were ranked of high quality in comparison of 69% of NA-ADNI. ICV showed homogeneous variances across scanners except for Siemens scanners at 3.0 Tesla (p = 0.039). A significant difference in hippocampal volume was found between AD and controls on 1.5 Tesla scans (p < 0.001), confirming known group validity test. Conclusion: This study has provided standardization of MRI acquisition and imaging marker collection across different Italian clinical units and equipment. This is a mandatory step to the implementation of imaging biomarkers in clinical routine for early and differential diagnosis.
2014
intracranial volume; alzheimer's disease; hippocampus; magnetic resonance imaging; mild cognitive impairment; standardized operating procedures
01 Pubblicazione su rivista::01a Articolo in rivista
The Italian Alzheimer's Disease Neuroimaging Initiative (I-ADNI): Validation of Structural MR Imaging / E., Cavedo; A., Redolfi; F., Angeloni; Babiloni, Claudio; Lizio, Roberta; L., Chiapparini; M. G., Bruzzone; D., Aquino; U., Sabatini; M., Alesiani; A., Cherubini; E., Salvatore; A., Soricelli; F., Vernieri; F., Scrascia; E., Sinforiani; P., Chiarati; S., Bastianello; P., Montella; D., Corbo; G., Tedeschi; S., Marino; A., Baglieri; S., De Salvo; Carducci, Filippo; C. C., Quattrocchi; M., Cobelli; G. B., Frisoni. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - 40:4(2014), pp. 941-952. [10.3233/jad-132666]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/559611
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