Diagnosis of CGD is made by demonstrating absent or markedly reduced oxidase activity in stimulated neutrophils. The screening test proposed is based upon the naked eye evaluation of the reduction of NBT on a solid surface. It seems to be a useful tool for rapid and inexpensive detection of CGD patients, especially for large-scale screening purposes. The test was carried out on forty-five subjects: two males affected by CGD, three female carriers and forty healthy donors. The test confirmed the results obtained with flow cytometric and NBT assays.

Improvement of a rapid screening test for chronic granulomatous disease / Iacobini, Metello; Duse, Marzia; DI COSTE, Annalisa; L., Balducci. - In: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. - ISSN 0394-6320. - STAMPA. - 26:3(2013), pp. 807-808.

Improvement of a rapid screening test for chronic granulomatous disease

IACOBINI, Metello;DUSE, MARZIA;DI COSTE, ANNALISA;
2013

Abstract

Diagnosis of CGD is made by demonstrating absent or markedly reduced oxidase activity in stimulated neutrophils. The screening test proposed is based upon the naked eye evaluation of the reduction of NBT on a solid surface. It seems to be a useful tool for rapid and inexpensive detection of CGD patients, especially for large-scale screening purposes. The test was carried out on forty-five subjects: two males affected by CGD, three female carriers and forty healthy donors. The test confirmed the results obtained with flow cytometric and NBT assays.
chronic granulomatous disease; screening test; screening; nitroblue tetrazolium chloride; chronic granulomatous-disease; nitro blue tetrazolium chloride
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Improvement of a rapid screening test for chronic granulomatous disease / Iacobini, Metello; Duse, Marzia; DI COSTE, Annalisa; L., Balducci. - In: INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY. - ISSN 0394-6320. - STAMPA. - 26:3(2013), pp. 807-808.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/558015
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