Background: Zygomycosis is a rare life-threatening fungal infection affecting mostly patients with predisposing conditions such as diabetes mellitus, immunodeficiency, haemochromatosis or major trauma. Methods. We describe a case of rhinocerebral zygomycosis in a girl with type 1 diabetes and review previous published cases and treatment options. Results: A 14-year-old girl with type 1 diabetes mellitus occurred with dental pain, facial swelling, ecchymosis and left eye decreased visual acuity, unresponsive to antibiotic therapy. The coltures of the sinusal mucosa were positive for fungal species belonging to the Zygomycetes. She performed antifungal therapy with posaconazole (POS) with a very slow improvement and a poor glycemic control, leading to blindness of the left eye. Conclusion: Our report adds further awareness on rhinocerebral zygomycosis and emphasizes on urgent diagnosis and timely management of this potentially fatal fungal infection through an adequate treatment. © 2013 di Coste et al.; licensee BioMed Central Ltd.

Rhinocerebral zygomycosis with pansinusitis in a 14-year-old girl with type 1 diabetes: a case report and review of the literature / DI COSTE, Annalisa; Costantino, Francesco; Tarani, Luigi; Vincenzo, Savastano; DI BIASI, Claudio; Laura, Schiavi; Ernesti, Ilaria; Melengu, Taulant; Duse, Marzia. - In: THE ITALIAN JOURNAL OF PEDIATRICS. - ISSN 1720-8424. - ELETTRONICO. - 39:1(2013). [10.1186/1824-7288-39-77]

Rhinocerebral zygomycosis with pansinusitis in a 14-year-old girl with type 1 diabetes: a case report and review of the literature

DI COSTE, ANNALISA;COSTANTINO, Francesco;TARANI, Luigi;DI BIASI, Claudio;ERNESTI, ILARIA;MELENGU, TAULANT;DUSE, MARZIA
2013

Abstract

Background: Zygomycosis is a rare life-threatening fungal infection affecting mostly patients with predisposing conditions such as diabetes mellitus, immunodeficiency, haemochromatosis or major trauma. Methods. We describe a case of rhinocerebral zygomycosis in a girl with type 1 diabetes and review previous published cases and treatment options. Results: A 14-year-old girl with type 1 diabetes mellitus occurred with dental pain, facial swelling, ecchymosis and left eye decreased visual acuity, unresponsive to antibiotic therapy. The coltures of the sinusal mucosa were positive for fungal species belonging to the Zygomycetes. She performed antifungal therapy with posaconazole (POS) with a very slow improvement and a poor glycemic control, leading to blindness of the left eye. Conclusion: Our report adds further awareness on rhinocerebral zygomycosis and emphasizes on urgent diagnosis and timely management of this potentially fatal fungal infection through an adequate treatment. © 2013 di Coste et al.; licensee BioMed Central Ltd.
pansinusitis; rhinocerebral zygomycosis; endoscopic sinus surgery; diabetes; maxillary sinus; posaconazole
01 Pubblicazione su rivista::01a Articolo in rivista
Rhinocerebral zygomycosis with pansinusitis in a 14-year-old girl with type 1 diabetes: a case report and review of the literature / DI COSTE, Annalisa; Costantino, Francesco; Tarani, Luigi; Vincenzo, Savastano; DI BIASI, Claudio; Laura, Schiavi; Ernesti, Ilaria; Melengu, Taulant; Duse, Marzia. - In: THE ITALIAN JOURNAL OF PEDIATRICS. - ISSN 1720-8424. - ELETTRONICO. - 39:1(2013). [10.1186/1824-7288-39-77]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/558002
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 6
social impact