The high frequency dynamics of Indomethacin and Celecoxib glasses has been investigated by inelastic X-ray scattering, accessing a momentum-energy region still unexplored in amorphous pharmaceuticals. We find evidence of phonon-like acoustic dynamics, and determine the THz behavior of sound velocity and acoustic attenuation. Connections with ordinary sound propagation are discussed, along with the relation between fast and slow degrees of freedom as represented by non-ergodicity factor and kinetic fragility, respectively.
Acoustic-like dynamics of amorphous drugs in the THz regime / E. A. A., Pogna; C., Rodriguez Tinoco; M., Krisch; J., Rodriguez Viejo; Scopigno, Tullio. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - ELETTRONICO. - 3:(2013). [10.1038/srep02518]
Acoustic-like dynamics of amorphous drugs in the THz regime.
SCOPIGNO, TULLIO
2013
Abstract
The high frequency dynamics of Indomethacin and Celecoxib glasses has been investigated by inelastic X-ray scattering, accessing a momentum-energy region still unexplored in amorphous pharmaceuticals. We find evidence of phonon-like acoustic dynamics, and determine the THz behavior of sound velocity and acoustic attenuation. Connections with ordinary sound propagation are discussed, along with the relation between fast and slow degrees of freedom as represented by non-ergodicity factor and kinetic fragility, respectively.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
