Glioblastoma (GBM) is the most common and aggressive form of brain tumor, characterized by high migratory behavior and infiltration in brain parenchyma which render classic therapeutic approach ineffective. The migratory behaviour of GBM cells could be conditioned by a number of tissue- and glioma-derived cytokines and growth factors. Although the pro-migratory action of CXCL12 on GBM cells in vitro and in vivo is recognized, the molecular mechanisms involved are not clearly identified. In fact the signaling pathways involved in the pro-migratory action of CXCL12 may differ in individual glioblastoma and integrate with those resulting from abnormal expression and activation of growth factor receptors. In this study we investigated whether some of the receptor tyrosine kinases commonly expressed in GBM cells could cooperate with CXCL12/CXCR4 in their migratory behavior. Our results show a functional cross-talk between CXCR4 and PDGFR which appears to be essential for GBM chemotaxis.

Functional cross talk between CXCR4 and PDGFR on glioblastoma cells is essential for migration / Sciaccaluga, Miriam; D'Alessandro, Giuseppina; Pagani, Francesca; Giuseppina, Ferrara; Nadia, Lopez; Tracy, Warr; Paolo, Gorello; Porzia, Alessandra; Mainiero, Fabrizio; Santoro, Antonio; Esposito, Vincenzo; Cantore, Giampaolo; Emilia, Castigli; Limatola, Cristina. - In: PLOS ONE. - ISSN 1932-6203. - STAMPA. - 8:9(2013), pp. 1-10. [10.1371/journal.pone.0073426]

Functional cross talk between CXCR4 and PDGFR on glioblastoma cells is essential for migration.

SCIACCALUGA, MIRIAM;D'ALESSANDRO, GIUSEPPINA;PAGANI, FRANCESCA;PORZIA, Alessandra;MAINIERO, Fabrizio;SANTORO, Antonio;ESPOSITO, Vincenzo;CANTORE, Giampaolo;LIMATOLA, Cristina
2013

Abstract

Glioblastoma (GBM) is the most common and aggressive form of brain tumor, characterized by high migratory behavior and infiltration in brain parenchyma which render classic therapeutic approach ineffective. The migratory behaviour of GBM cells could be conditioned by a number of tissue- and glioma-derived cytokines and growth factors. Although the pro-migratory action of CXCL12 on GBM cells in vitro and in vivo is recognized, the molecular mechanisms involved are not clearly identified. In fact the signaling pathways involved in the pro-migratory action of CXCL12 may differ in individual glioblastoma and integrate with those resulting from abnormal expression and activation of growth factor receptors. In this study we investigated whether some of the receptor tyrosine kinases commonly expressed in GBM cells could cooperate with CXCL12/CXCR4 in their migratory behavior. Our results show a functional cross-talk between CXCR4 and PDGFR which appears to be essential for GBM chemotaxis.
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/556144
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 18
  • Scopus 25
  • ???jsp.display-item.citation.isi??? 26
social impact