The combination of the severity of pediatric-onset inflammatory bowel disease (IBD) phenotypes and the need for intense medical treatment may increase the risk of malignancy and mortality, but evidence regarding the extent of the problem is scarce. Therefore, the Porto Pediatric IBD working group of ESPGHAN conducted a multinational-based survey of cancer and mortality in pediatric IBD. Methods: A survey among pediatric gastroenterologists of 20 European countries and Israel on cancer and/or mortality in the pediatric patient population with IBD was undertaken. One representative from each country repeatedly contacted all pediatric gastroenterologists from each country for reporting retrospectively cancer and/or mortality of pediatric patients with IBD after IBD onset, during 2006–2011. Results: We identified 18 cases of cancers and/or 31 deaths in 44 children (26 males) who were diagnosed with IBD (ulcerative colitis, n ¼ 21) at a median age of 10.0 years
Malignancy and Mortality in Pediatric Patients with Inflammatory Bowel Disease: A Multinational Study from the Porto Pediatric IBD Group / Javier Martin de, Carpi; Ulrika L., Fagerberg; Christine, Spray; Malgorzata, Sladek; Ron, Shaoul; Eleftheria Roma, Giannikou; Jiri, Bronsky; Daniela E., Serban; Cucchiara, Salvatore; Gabor, Veres; Frank M., Ruemmele; Iva, Hojsak; Kaija L., Kolho; Ieuan H., Davies; Aloi, Marina; Paolo, Lionetti; Gigi Veereman, Wauters; Christian P., Braegger; Eunice, Trindade; Anne V., Wewer; Almuthe, Hauer; Arie, Levine. - In: INFLAMMATORY BOWEL DISEASES. - ISSN 1536-4844. - ELETTRONICO. - 20:2(2014), pp. 291-300. [10.1097/01.MIB.0000439066.69340.3c]
Malignancy and Mortality in Pediatric Patients with Inflammatory Bowel Disease: A Multinational Study from the Porto Pediatric IBD Group
CUCCHIARA, Salvatore;ALOI, MARINA;
2014
Abstract
The combination of the severity of pediatric-onset inflammatory bowel disease (IBD) phenotypes and the need for intense medical treatment may increase the risk of malignancy and mortality, but evidence regarding the extent of the problem is scarce. Therefore, the Porto Pediatric IBD working group of ESPGHAN conducted a multinational-based survey of cancer and mortality in pediatric IBD. Methods: A survey among pediatric gastroenterologists of 20 European countries and Israel on cancer and/or mortality in the pediatric patient population with IBD was undertaken. One representative from each country repeatedly contacted all pediatric gastroenterologists from each country for reporting retrospectively cancer and/or mortality of pediatric patients with IBD after IBD onset, during 2006–2011. Results: We identified 18 cases of cancers and/or 31 deaths in 44 children (26 males) who were diagnosed with IBD (ulcerative colitis, n ¼ 21) at a median age of 10.0 yearsI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
