Serine and glycine are biosynthetically linked, and together provide the essential precursors for the synthesis of proteins, nucleic acids, and lipids that are crucial to cancer cell growth. Moreover, serine/glycine biosynthesis also affects cellular antioxidative capacity, thus supporting tumour homeostasis. A crucial contribution of serine/glycine to cellular metabolism is through the glycine cleavage system, which refuels one-carbon metabolism; a complex cyclic metabolic network based on chemical reactions of folate compounds. The importance of serine/glycine metabolism is further highlighted by genetic and functional evidence indicating that hyperactivation of the serine/glycine biosynthetic pathway drives oncogenesis. Recent developments in our understanding of these pathways provide novel translational opportunities for drug development, dietary intervention, and biomarker identification of human cancers.

Serine and glycine metabolism in cancer / Amelio, I; Cutruzzola', Francesca; Antonov, A; Agostini, M; Melino, G.. - In: TRENDS IN BIOCHEMICAL SCIENCES. - ISSN 0968-0004. - 39:4(2014), pp. 191-198. [10.1016/j.tibs.2014.02.004]

Serine and glycine metabolism in cancer.

CUTRUZZOLA', Francesca;
2014

Abstract

Serine and glycine are biosynthetically linked, and together provide the essential precursors for the synthesis of proteins, nucleic acids, and lipids that are crucial to cancer cell growth. Moreover, serine/glycine biosynthesis also affects cellular antioxidative capacity, thus supporting tumour homeostasis. A crucial contribution of serine/glycine to cellular metabolism is through the glycine cleavage system, which refuels one-carbon metabolism; a complex cyclic metabolic network based on chemical reactions of folate compounds. The importance of serine/glycine metabolism is further highlighted by genetic and functional evidence indicating that hyperactivation of the serine/glycine biosynthetic pathway drives oncogenesis. Recent developments in our understanding of these pathways provide novel translational opportunities for drug development, dietary intervention, and biomarker identification of human cancers.
2014
Cancer metabolism; serine; folate
01 Pubblicazione su rivista::01a Articolo in rivista
Serine and glycine metabolism in cancer / Amelio, I; Cutruzzola', Francesca; Antonov, A; Agostini, M; Melino, G.. - In: TRENDS IN BIOCHEMICAL SCIENCES. - ISSN 0968-0004. - 39:4(2014), pp. 191-198. [10.1016/j.tibs.2014.02.004]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/553087
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