Maintenance of mitotic cell clusters such as meristematic cells depends on their capacity to maintain the balance between cell division and cell differentiation necessary to control organ growth. In the Arabidopsis thaliana root meristem, the antagonistic interaction of two hormones, auxin and cytokinin, regulates this balance by positioning the transition zone, where mitotically active cells lose their capacity to divide and initiate their differentiation programs. In animals, a major regulator of both cell division and cell differentiation is the tumor suppressor protein RETINOBLASTOMA. Here, we show that similarly to its homolog in animal systems, the plant RETINOBLASTOMA-RELATED (RBR) protein regulates the differentiation of meristematic cells at the transition zone by allowing mRNA accumulation of AUXIN RESPONSE FACTOR19 (ARF19), a transcription factor involved in cell differentiation. We show that both RBR and the cytokinin-dependent transcription factor ARABIDOPSIS RESPONSE REGULATOR12 are required to activate the transcription of ARF19, which is involved in promoting cell differentiation and thus root growth.

RETINOBLASTOMA-RELATED protein stimulates cell differentiation in the Arabidopsis root meristem by interacting with cytokinin signaling / Perilli, Serena; Jose Manuel Perez, Perez; DI MAMBRO, Riccardo; Cristina Llavata, Peris; Sara Diaz, Trivino; Pierdonati, Emanuela; Moubayidin, Laila; Alfredo Cruz, Ramirez; Costantino, Paolo; Ben, Scheres; Sabatini, Sabrina; DEL BIANCO, Marta. - In: PLANT CELL. - ISSN 1040-4651. - STAMPA. - 25:11(2013), pp. 4469-4478. [10.1105/tpc.113.116632]

RETINOBLASTOMA-RELATED protein stimulates cell differentiation in the Arabidopsis root meristem by interacting with cytokinin signaling

PERILLI, SERENA;DI MAMBRO, RICCARDO;PIERDONATI, EMANUELA;MOUBAYIDIN, LAILA;COSTANTINO, Paolo;SABATINI, Sabrina;DEL BIANCO, Marta
2013

Abstract

Maintenance of mitotic cell clusters such as meristematic cells depends on their capacity to maintain the balance between cell division and cell differentiation necessary to control organ growth. In the Arabidopsis thaliana root meristem, the antagonistic interaction of two hormones, auxin and cytokinin, regulates this balance by positioning the transition zone, where mitotically active cells lose their capacity to divide and initiate their differentiation programs. In animals, a major regulator of both cell division and cell differentiation is the tumor suppressor protein RETINOBLASTOMA. Here, we show that similarly to its homolog in animal systems, the plant RETINOBLASTOMA-RELATED (RBR) protein regulates the differentiation of meristematic cells at the transition zone by allowing mRNA accumulation of AUXIN RESPONSE FACTOR19 (ARF19), a transcription factor involved in cell differentiation. We show that both RBR and the cytokinin-dependent transcription factor ARABIDOPSIS RESPONSE REGULATOR12 are required to activate the transcription of ARF19, which is involved in promoting cell differentiation and thus root growth.
2013
Arabidopsis; Arabidopsis Proteins; Cell Differentiation; Cytokinins; Gene Expression Regulation, Plant; Meristem; Plant Roots; Plants, Genetically Modified; Protein Kinases; Signal Transduction; Transcription Factors; Plant Science; Cell Biology
01 Pubblicazione su rivista::01a Articolo in rivista
RETINOBLASTOMA-RELATED protein stimulates cell differentiation in the Arabidopsis root meristem by interacting with cytokinin signaling / Perilli, Serena; Jose Manuel Perez, Perez; DI MAMBRO, Riccardo; Cristina Llavata, Peris; Sara Diaz, Trivino; Pierdonati, Emanuela; Moubayidin, Laila; Alfredo Cruz, Ramirez; Costantino, Paolo; Ben, Scheres; Sabatini, Sabrina; DEL BIANCO, Marta. - In: PLANT CELL. - ISSN 1040-4651. - STAMPA. - 25:11(2013), pp. 4469-4478. [10.1105/tpc.113.116632]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/551873
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