Background: The recurrence of hepatitis C viral infection is common after liver transplant, and achieving a sustained virological response to antiviral treatment is desirable for reducing the risk of graft loss and improving patients' survival. Aim: To investigate the long-term maintenance of sustained virological response in liver transplant recipients with hepatitis C recurrence. Methods: 436 Liver transplant recipients (74.1% genotype 1) who underwent combined antiviral therapy for hepatitis C recurrence were retrospectively evaluated. Results: The overall sustained virological response rate was 40% (173/436 patients), and the mean follow-up after liver transplantation was 11 ± 3.5 years (range, 5-24). Patients with a sustained virological response demonstrated a 5-year survival rate of 97% and a 10-year survival rate of 93%; all but 6 (3%) patients remained hepatitis C virus RNA-negative during follow-up. Genotype non-1 (p = 0.007), treatment duration >80% of the scheduled period (p = 0.027), and early virological response (p = 0.002), were associated with the maintenance of sustained virological response as indicated by univariate analysis. Early virological response was the only independent predictor of sustained virological response maintenance (p = 0.008). Conclusions: Sustained virological response achieved after combined antiviral treatment is maintained in liver transplant patients with recurrent hepatitis C and is associated with an excellent 5-year survival. © 2014 Editrice Gastroenterologica Italiana S.r.l.

Long-term maintenance of sustained virological response in liver transplant recipients treated for recurrent hepatitis C / Francesca Romana, Ponziani; Raffaella, Vigano; Rosa Maria, Iemmolo; Maria Francesca, Donato; Maria, Rendina; Pierluigi, Toniutto; Luisa, Pasulo; Maria Cristina, Morelli; Patrizia, Burra; Lucia, Miglioresi; Merli, Manuela; Daniele Di, Paolo; Stefano, Fagiuoli; Antonio, Gasbarrini; Maurizio, Pompili; L., Belli; G. e., Gerunda; M., Marino; R., Montalti; F., Di Benedetto; N., De Ruvo; C., Rigamonti; M., Colombo; G., Rossi; A., Di Leo; L., Lupo; V., Memeo; R., Bringiotti; M., Zappimbulso; D., Bitetto; V., Vero; M., Colpani; E., Fornasiere; A. d., Pinna; M. c., Morelli; V., Bertuzzo; E., De Martin; M., Senzolo; G. m., Ettorre; U., Visco Comandini; G., Antonucci; M., Angelico; G., Tisone; Giannelli, Valerio; Giusto, Michela. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - STAMPA. - 46:5(2014), pp. 440-445. [10.1016/j.dld.2014.01.157]

Long-term maintenance of sustained virological response in liver transplant recipients treated for recurrent hepatitis C

MERLI, Manuela;GIANNELLI, VALERIO;GIUSTO, MICHELA
2014

Abstract

Background: The recurrence of hepatitis C viral infection is common after liver transplant, and achieving a sustained virological response to antiviral treatment is desirable for reducing the risk of graft loss and improving patients' survival. Aim: To investigate the long-term maintenance of sustained virological response in liver transplant recipients with hepatitis C recurrence. Methods: 436 Liver transplant recipients (74.1% genotype 1) who underwent combined antiviral therapy for hepatitis C recurrence were retrospectively evaluated. Results: The overall sustained virological response rate was 40% (173/436 patients), and the mean follow-up after liver transplantation was 11 ± 3.5 years (range, 5-24). Patients with a sustained virological response demonstrated a 5-year survival rate of 97% and a 10-year survival rate of 93%; all but 6 (3%) patients remained hepatitis C virus RNA-negative during follow-up. Genotype non-1 (p = 0.007), treatment duration >80% of the scheduled period (p = 0.027), and early virological response (p = 0.002), were associated with the maintenance of sustained virological response as indicated by univariate analysis. Early virological response was the only independent predictor of sustained virological response maintenance (p = 0.008). Conclusions: Sustained virological response achieved after combined antiviral treatment is maintained in liver transplant patients with recurrent hepatitis C and is associated with an excellent 5-year survival. © 2014 Editrice Gastroenterologica Italiana S.r.l.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/549401
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