Necroptosis is a form of programmed necrosis whose molecular players are partially shared with apoptotic cell death. Here we summarize what is known about molecular signalling of necroptosis, particularly focusing on fine tuning of FLIP and IAP proteins in the apoptosis/necroptosis balance. We also emphasize necroptosis involvement in physiological and pathological conditions, particularly in the regulation of immune homeostasis.
Necroptosis is a form of programmed necrosis whose molecular players are partially shared with apoptotic cell death. Here we summarize what is known about molecular signalling of necroptosis, particularly focusing on fine tuning of FLIP and IAP proteins in the apoptosis/necroptosis balance. We also emphasize necroptosis involvement in physiological and pathological conditions, particularly in the regulation of immune homeostasis.
Necroptosis: Molecular signalling and translational implications / Giampietri, Claudia; Starace, Donatella; Petrungaro, Simonetta; Filippini, Antonio; Ziparo, Elio. - In: INTERNATIONAL JOURNAL OF CELL BIOLOGY. - ISSN 1687-8876. - 2014:(2014), pp. 1-6. [10.1155/2014/490275]
Necroptosis: Molecular signalling and translational implications
GIAMPIETRI, Claudia;STARACE, Donatella;PETRUNGARO, Simonetta;FILIPPINI, Antonio;ZIPARO, Elio
2014
Abstract
Necroptosis is a form of programmed necrosis whose molecular players are partially shared with apoptotic cell death. Here we summarize what is known about molecular signalling of necroptosis, particularly focusing on fine tuning of FLIP and IAP proteins in the apoptosis/necroptosis balance. We also emphasize necroptosis involvement in physiological and pathological conditions, particularly in the regulation of immune homeostasis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
