Objective The objective of this paper is to assess the validity of a linguistically validated version of the Lupus Quality of Life (LupusQoL©) in Italian patients affected by systemic lupus erythematosus (SLE).MethodsConsecutive SLE patients completed the Italian version of the LupusQoL© and the Short Form (SF)-36. Disease activity was evaluated by the SLE disease activity Index-2000 (SLEDAI-2 K), and chronic damage by the Systemic Lupus International Collaborating Clinics/American College Rheumatology (ACR) Damage Index score (SDI). Internal consistency and test-retest reliability, convergent and discriminant validity were examined. Factor analysis with varimax rotation was performed.ResultsA total of 117 Italian SLE patients (M:F 13:104; mean age 40.6 ± 11.6 years, mean disease duration 127.5 ± 94.1 months) were recruited into the study. The Italian version of the LupusQoL© demonstrated substantial evidence of convergent validity in these patients when compared with equivalent items of the SF-36. In addition, the LupusQoL© discriminated between patients with different degrees of disease activity as measured by the SLEDAI-2 K. SLE patients with higher disease activity (SLEDAI-2K ≥4) showed poor QoL compared with those with lower disease activity (SLEDAI-2K <4), with significant differences in the domains of physical health, planning, burden to others and fatigue (p = 0.001, p = 0.04, p = 0.03, p = 0.04, respectively). The confirmatory factor analysis using the eight domain loadings of the 34 items showed a poor fit (χ2/degree of freedom (df) 2.26, χ2 = 1128.6 (p < 0.001), root mean square error of approximation (RMSEA) = 0.167; goodness-of-fit index (GFI) = 0.606, comparative fit index (CFI) = 0.649)). Screeplot analysis suggested a five-factor loading structure and confirmatory factor analysis result of which is similar to the eight-factor model. A good internal consistency was observed (Cronbach's α 0.89-0.91). Test-retest reliability was good to excellent between baseline and day 15 (intraclass correlation coefficient (ICC) 0.90-0.98).ConclusionThe Italian version of the LupusQoL© is a valid tool for adult patients with SLE.

Validation of a disease-specific health-related quality of life measure in adult Italian patients with systemic lupus erythematosus: LupusQoL-IT / Conti, Fabrizio; Perricone, Carlo; Reboldi, G; Gawlicki, M; Bartosiewicz, Izabella; Pacucci, VIVIANA ANTONELLA; Massaro, Laura; Miranda, Francesca; Truglia, Simona; Alessandri, Cristiano; Spinelli, FRANCESCA ROMANA; Teh, Ls; Ceccarelli, Fulvia; Valesini, Guido. - In: LUPUS. - ISSN 0961-2033. - STAMPA. - 23:(2014), pp. 743-751. [10.1177/0961203314524466]

Validation of a disease-specific health-related quality of life measure in adult Italian patients with systemic lupus erythematosus: LupusQoL-IT.

CONTI, FABRIZIO;PERRICONE, CARLO;BARTOSIEWICZ, IZABELLA;PACUCCI, VIVIANA ANTONELLA;MASSARO, LAURA;MIRANDA, FRANCESCA;TRUGLIA, SIMONA;ALESSANDRI, cristiano;SPINELLI, FRANCESCA ROMANA;CECCARELLI, FULVIA;VALESINI, Guido
2014

Abstract

Objective The objective of this paper is to assess the validity of a linguistically validated version of the Lupus Quality of Life (LupusQoL©) in Italian patients affected by systemic lupus erythematosus (SLE).MethodsConsecutive SLE patients completed the Italian version of the LupusQoL© and the Short Form (SF)-36. Disease activity was evaluated by the SLE disease activity Index-2000 (SLEDAI-2 K), and chronic damage by the Systemic Lupus International Collaborating Clinics/American College Rheumatology (ACR) Damage Index score (SDI). Internal consistency and test-retest reliability, convergent and discriminant validity were examined. Factor analysis with varimax rotation was performed.ResultsA total of 117 Italian SLE patients (M:F 13:104; mean age 40.6 ± 11.6 years, mean disease duration 127.5 ± 94.1 months) were recruited into the study. The Italian version of the LupusQoL© demonstrated substantial evidence of convergent validity in these patients when compared with equivalent items of the SF-36. In addition, the LupusQoL© discriminated between patients with different degrees of disease activity as measured by the SLEDAI-2 K. SLE patients with higher disease activity (SLEDAI-2K ≥4) showed poor QoL compared with those with lower disease activity (SLEDAI-2K <4), with significant differences in the domains of physical health, planning, burden to others and fatigue (p = 0.001, p = 0.04, p = 0.03, p = 0.04, respectively). The confirmatory factor analysis using the eight domain loadings of the 34 items showed a poor fit (χ2/degree of freedom (df) 2.26, χ2 = 1128.6 (p < 0.001), root mean square error of approximation (RMSEA) = 0.167; goodness-of-fit index (GFI) = 0.606, comparative fit index (CFI) = 0.649)). Screeplot analysis suggested a five-factor loading structure and confirmatory factor analysis result of which is similar to the eight-factor model. A good internal consistency was observed (Cronbach's α 0.89-0.91). Test-retest reliability was good to excellent between baseline and day 15 (intraclass correlation coefficient (ICC) 0.90-0.98).ConclusionThe Italian version of the LupusQoL© is a valid tool for adult patients with SLE.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/547492
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