Migraine is a common and disabling neurological disease. The pathomechanism that underlies the disorder is not entirely understood, and reliable biomarkers are missing. In the current analysis we looked for microstructural alterations of the brain white matter in migraine patients by means of diffusion-weighted magnetic resonance imaging. The measurements were carried out with a novel approach based on fine-tuned nonlinear registration and nonparametric permutation test in an alignment-invariant tract representation (Tract-Based Spatial Statistics). We found reduced fractional anisotropy in the right frontal white matter cluster of migraine patients. In the same region we also found increased mean diffusivity and increased radial diffusivity. The probabilistic tractography showed connection of this cluster to other parts of the pain network (orbitofrontal cortex, insula, thalamus, dorsal midbrain). We speculate that these findings reflect maladaptive plastic changes or white matter disintegration.

White matter microstructural alterations in migraine: a diffusion-weighted MRI study / N., Szabó; Z. T., Kincses; A., Párdutz; J., Tajti; D., Szok; B., Tuka; A., Király; M., Babos; E., Vörös; Bomboi, Giuseppe; Orzi, Francesco; L., Vécsei. - In: PAIN. - ISSN 0304-3959. - STAMPA. - 153:(2012), pp. 651-656. [10.1016/j.pain.2011.11.029]

White matter microstructural alterations in migraine: a diffusion-weighted MRI study.

BOMBOI, GIUSEPPE;ORZI, Francesco;
2012

Abstract

Migraine is a common and disabling neurological disease. The pathomechanism that underlies the disorder is not entirely understood, and reliable biomarkers are missing. In the current analysis we looked for microstructural alterations of the brain white matter in migraine patients by means of diffusion-weighted magnetic resonance imaging. The measurements were carried out with a novel approach based on fine-tuned nonlinear registration and nonparametric permutation test in an alignment-invariant tract representation (Tract-Based Spatial Statistics). We found reduced fractional anisotropy in the right frontal white matter cluster of migraine patients. In the same region we also found increased mean diffusivity and increased radial diffusivity. The probabilistic tractography showed connection of this cluster to other parts of the pain network (orbitofrontal cortex, insula, thalamus, dorsal midbrain). We speculate that these findings reflect maladaptive plastic changes or white matter disintegration.
Adult, Anisotropy, Brain Mapping, Brain; pathology, Diffusion Magnetic Resonance Imaging, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Migraine Disorders; pathology, Nerve Fibers; Myelinated; pathology, Statistics; Nonparametric, Young Adult
01 Pubblicazione su rivista::01a Articolo in rivista
White matter microstructural alterations in migraine: a diffusion-weighted MRI study / N., Szabó; Z. T., Kincses; A., Párdutz; J., Tajti; D., Szok; B., Tuka; A., Király; M., Babos; E., Vörös; Bomboi, Giuseppe; Orzi, Francesco; L., Vécsei. - In: PAIN. - ISSN 0304-3959. - STAMPA. - 153:(2012), pp. 651-656. [10.1016/j.pain.2011.11.029]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/547310
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