We investigated possible changes of parameters of calcium metabolism induced by strontium ranelate (SR). Twenty-three patients with postmenopausal osteoporosis (PO) and 14 with primary hyperparathyroidism (PHPT) were studied while taking 2 g/day of SR. Women with PO and 10 healthy age-matched control women were also daily supplemented with 1,000 mg calcium and 800 IU vitamin D. All subjects were studied at baseline and after 7 and 30 days; PO women and controls were also investigated at 180 and 360 days of treatment. Serum ionized calcium (iCa), phosphate (sP), magnesium, creatinine, 25-hydroxycholecalciferol (25[OH]D), 1,25-dihydroxycholecalciferol (1,25[OH](2)D), serum parathyroid hormone (PTH) were measured. In spot urine, we assessed calcium and phosphate over creatinine ratios (uCa/Cr, uP/Cr), calcium excretion (Ca ex) and renal phosphate threshold (TmP/GFR); in 24-h urine, calcium and magnesium over creatinine clearance ratios (CaCl/CrCl and MgCl/CrCl). In PO, SR administration was associated with a significant decrease of PTH and 1,25(OH)(2)D levels but an increase of sP (p < 0.001). SR also significantly increased Ca/Cr, Ca ex, and TmP/GFR in spot urine and CaCl/CrCl in both spot and 24-h urine (p = 0.004 to < 0.001). In PHPT, SR significantly decreased iCa and increased sP, slightly modifying PTH, 25(OH)D, and 1,25(OH)(2)D values. Also in PHPT, Ca ex and CaCl/CrCl of spot and 24-h urine, as TmP/GFR, significantly increased (all p < 0.02). SR influenced the main parameters of calcium homeostasis, probably through the calcium-sensing receptor.

Effects of Strontium Ranelate Administration on Calcium Metabolism in Female Patients with Postmenopausal Osteoporosis and Primary Hyperparathyroidism / Vincenzo, Carnevale; Romano Del, Fiacco; Elisabetta, Romagnoli; Andrea, Fontana; Cipriani, Cristiana; Pepe, Jessica; Minisola, Salvatore. - In: CALCIFIED TISSUE INTERNATIONAL. - ISSN 0171-967X. - 92:1(2013), pp. 15-22. [10.1007/s00223-012-9659-5]

Effects of Strontium Ranelate Administration on Calcium Metabolism in Female Patients with Postmenopausal Osteoporosis and Primary Hyperparathyroidism

CIPRIANI, Cristiana;PEPE, JESSICA;MINISOLA, Salvatore
2013

Abstract

We investigated possible changes of parameters of calcium metabolism induced by strontium ranelate (SR). Twenty-three patients with postmenopausal osteoporosis (PO) and 14 with primary hyperparathyroidism (PHPT) were studied while taking 2 g/day of SR. Women with PO and 10 healthy age-matched control women were also daily supplemented with 1,000 mg calcium and 800 IU vitamin D. All subjects were studied at baseline and after 7 and 30 days; PO women and controls were also investigated at 180 and 360 days of treatment. Serum ionized calcium (iCa), phosphate (sP), magnesium, creatinine, 25-hydroxycholecalciferol (25[OH]D), 1,25-dihydroxycholecalciferol (1,25[OH](2)D), serum parathyroid hormone (PTH) were measured. In spot urine, we assessed calcium and phosphate over creatinine ratios (uCa/Cr, uP/Cr), calcium excretion (Ca ex) and renal phosphate threshold (TmP/GFR); in 24-h urine, calcium and magnesium over creatinine clearance ratios (CaCl/CrCl and MgCl/CrCl). In PO, SR administration was associated with a significant decrease of PTH and 1,25(OH)(2)D levels but an increase of sP (p < 0.001). SR also significantly increased Ca/Cr, Ca ex, and TmP/GFR in spot urine and CaCl/CrCl in both spot and 24-h urine (p = 0.004 to < 0.001). In PHPT, SR significantly decreased iCa and increased sP, slightly modifying PTH, 25(OH)D, and 1,25(OH)(2)D values. Also in PHPT, Ca ex and CaCl/CrCl of spot and 24-h urine, as TmP/GFR, significantly increased (all p < 0.02). SR influenced the main parameters of calcium homeostasis, probably through the calcium-sensing receptor.
2013
calcium sensing receptor; parathyroid hormone; strontium ranelate; urinary calcium
01 Pubblicazione su rivista::01a Articolo in rivista
Effects of Strontium Ranelate Administration on Calcium Metabolism in Female Patients with Postmenopausal Osteoporosis and Primary Hyperparathyroidism / Vincenzo, Carnevale; Romano Del, Fiacco; Elisabetta, Romagnoli; Andrea, Fontana; Cipriani, Cristiana; Pepe, Jessica; Minisola, Salvatore. - In: CALCIFIED TISSUE INTERNATIONAL. - ISSN 0171-967X. - 92:1(2013), pp. 15-22. [10.1007/s00223-012-9659-5]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/543836
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