The aggregation behavior of a cationic derivative of cholic acid {[3b,5b,7a,12a]-3-(2-naphthoylamino)-7,12- dihydroxycholan-24-triethylamonium iodide} has been studied by surface tension measurements, fluorescence spectroscopy, transmission electronic microscopy (TEM), and circular dichroism. The critical aggregation concentration, the fraction of bound counterions and thermodynamic parameters for the formation of aggregates have been determined, as well as the morphology of the aggregates. TEM images support a consecutive transformation mechanism from fibers to tubules, these having a well-defined geometry and being the only structure observed at the end of the process. Intermediate observed structures are helical ribbons.
The aggregation behavior of a cationic derivative of cholic acid {[3 beta, 5 beta, 7 alpha, 12 alpha]-3-(2-naphthoylamino)-7,12-dihydroxycholan- 24-triethylamonium iodide} has been studied by surface tension measurements, fluorescence spectroscopy, transmission electronic microscopy (TEM), and circular dichroism. The critical aggregation concentration, the fraction of bound counterions and thermodynamic parameters for the formation of aggregates have been determined, as well as the morphology of the aggregates. TEM images support a consecutive transformation mechanism from fibers to tubules, these having a well-defined geometry and being the only structure observed at the end of the process. Intermediate observed structures are helical ribbons.
Self-aggregation mechanism of a naphthylamide cationic derivative of cholic acid. From fibers to tubules / Trillo, Juan V.; Meijide, Francisco; Jover, Aida; Soto, Victor H.; de Frutos, Santiago; di Gregorio, Maria Chiara; Galantini, Luciano; Tato, José Vàzquez. - In: RSC ADVANCES. - ISSN 2046-2069. - 4:11(2014), pp. 5598-5606. [10.1039/c3ra47160h]
Self-aggregation mechanism of a naphthylamide cationic derivative of cholic acid. From fibers to tubules
di Gregorio, Maria Chiara;Galantini, Luciano;
2014
Abstract
The aggregation behavior of a cationic derivative of cholic acid {[3b,5b,7a,12a]-3-(2-naphthoylamino)-7,12- dihydroxycholan-24-triethylamonium iodide} has been studied by surface tension measurements, fluorescence spectroscopy, transmission electronic microscopy (TEM), and circular dichroism. The critical aggregation concentration, the fraction of bound counterions and thermodynamic parameters for the formation of aggregates have been determined, as well as the morphology of the aggregates. TEM images support a consecutive transformation mechanism from fibers to tubules, these having a well-defined geometry and being the only structure observed at the end of the process. Intermediate observed structures are helical ribbons.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
