The neural circuits mediating fear to naturalistic threats are poorly understood. We found that functionally independent populations of neurons in the ventromedial hypothalamus (VMH), a region that has been implicated in feeding, sex and aggression, are essential for predator and social fear in mice. Our results establish a critical role for VMH in fear and have implications for selective intervention in pathological fear in humans.

Independent hypothalamic circuits for social and predator fear / Bianca A., Silva; Camilla, Mattucci; Piotr, Krzywkowski; Murana, Emanuele; Anna, Illarionova; Valery, Grinevich; Newton S., Canteras; Ragozzino, Davide Antonio; T., Gross Cornelius. - In: NATURE NEUROSCIENCE. - ISSN 1097-6256. - STAMPA. - 16:12(2013), pp. 1731-1733. [10.1038/nn.3573]

Independent hypothalamic circuits for social and predator fear

MURANA, EMANUELE;RAGOZZINO, Davide Antonio;
2013

Abstract

The neural circuits mediating fear to naturalistic threats are poorly understood. We found that functionally independent populations of neurons in the ventromedial hypothalamus (VMH), a region that has been implicated in feeding, sex and aggression, are essential for predator and social fear in mice. Our results establish a critical role for VMH in fear and have implications for selective intervention in pathological fear in humans.
2013
social fear; fear circuits; ventromedial hypothalamus
01 Pubblicazione su rivista::01a Articolo in rivista
Independent hypothalamic circuits for social and predator fear / Bianca A., Silva; Camilla, Mattucci; Piotr, Krzywkowski; Murana, Emanuele; Anna, Illarionova; Valery, Grinevich; Newton S., Canteras; Ragozzino, Davide Antonio; T., Gross Cornelius. - In: NATURE NEUROSCIENCE. - ISSN 1097-6256. - STAMPA. - 16:12(2013), pp. 1731-1733. [10.1038/nn.3573]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/543230
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