Besides the control of calcium levels, the Phosphoinositide-specific phospholipases C (PI-PLCs), main players in the Phosphoinositide signalling pathway, contribute to a number of cell activities. The signalling system of Phosphoinositides (PIs) is involved in a variety of cell and tissue functions, including membrane trafficking, ion channel activity, cell cycle, apoptosis, differentiation, cell and tissue polarity. Recently, a role in cell migration was hypothesized for PI and related molecules, such as the phosphoinositide-specific phospholipases C (PI-PLCs), main players in PI signalling. The expression of PI-PLCs is tissue specific, and evidences suggest that it varies under different conditions, such as tumour progression or cell activation. In order to obtain a complete panel, we first analyzed the expression of all PI-PLC isoforms in human endothelial cells (EC). We investigated the human umbilical vein endothelial cells (HUVEC), a widely used experimental model. Then, we analy
The involvement of Phosphoinositide signal transduction pathway in angiogenesis / LO VASCO, VINCENZA RITA. - ELETTRONICO. - 2014 MCB Handbook:(2014), pp. 56-57. (Intervento presentato al convegno TM’s 3rd World Molecular & Cell Biology Online Conference tenutosi a Houston, USA nel 25-28 Frebruary).
The involvement of Phosphoinositide signal transduction pathway in angiogenesis.
LO VASCO, VINCENZA RITA
2014
Abstract
Besides the control of calcium levels, the Phosphoinositide-specific phospholipases C (PI-PLCs), main players in the Phosphoinositide signalling pathway, contribute to a number of cell activities. The signalling system of Phosphoinositides (PIs) is involved in a variety of cell and tissue functions, including membrane trafficking, ion channel activity, cell cycle, apoptosis, differentiation, cell and tissue polarity. Recently, a role in cell migration was hypothesized for PI and related molecules, such as the phosphoinositide-specific phospholipases C (PI-PLCs), main players in PI signalling. The expression of PI-PLCs is tissue specific, and evidences suggest that it varies under different conditions, such as tumour progression or cell activation. In order to obtain a complete panel, we first analyzed the expression of all PI-PLC isoforms in human endothelial cells (EC). We investigated the human umbilical vein endothelial cells (HUVEC), a widely used experimental model. Then, we analyI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
