Glycolysis is the central axis of cellular metabolism. The cancer cell bioenergetic status heavily relies on high glycolytic rates, even in aerobic conditions, thus sustaining the expensive processes of cell growth and proliferation. Growing evidences show that signaling aberrations - especially those involving PI3K/Akt/mTOR, HIF1a, Ras/Raf/MEK/ERK - are strictly connected to the establishment of a pro-glycolytic metabolism, through a multi-level crosstalk between proteins and metabolites that contribute to the acquisition of an energetic background granting a proliferative advantage. Here we investigated the glycolytic rate of resting and activated normal peripheral blood lymphocytes (NPBLs) and of acute myeloid leukemia (AML) cell lines. In an attempt to modulate the cellular metabolism for therapeutic intervention, we tested the following compounds that directly interfere with major metabolic or signaling pathways: dichloroacetate (DCA), a glycolysis inhibitor; aminooxyacetate (AOA)

Modulation of the glycolytic metabolism in acute myeloid leukemia cells / Mirabilii, Simone; Ricciardi, Maria Rosaria; Allegretti, Matteo; Licchetta, Roberto; M., Vincenzi; R., Nicolai; Foa, Roberto; Tafuri, Agostino. - In: BLOOD. - ISSN 0006-4971. - ELETTRONICO. - 122:(2013). (Intervento presentato al convegno American Society of Hematology (ASH) 55th Annual Meeting tenutosi a New Orleans, Louisiana, USA nel December 7 - 10, 2013).

Modulation of the glycolytic metabolism in acute myeloid leukemia cells

MIRABILII, SIMONE;RICCIARDI, Maria Rosaria;ALLEGRETTI, MATTEO;LICCHETTA, ROBERTO;FOA, Roberto;TAFURI, Agostino
2013

Abstract

Glycolysis is the central axis of cellular metabolism. The cancer cell bioenergetic status heavily relies on high glycolytic rates, even in aerobic conditions, thus sustaining the expensive processes of cell growth and proliferation. Growing evidences show that signaling aberrations - especially those involving PI3K/Akt/mTOR, HIF1a, Ras/Raf/MEK/ERK - are strictly connected to the establishment of a pro-glycolytic metabolism, through a multi-level crosstalk between proteins and metabolites that contribute to the acquisition of an energetic background granting a proliferative advantage. Here we investigated the glycolytic rate of resting and activated normal peripheral blood lymphocytes (NPBLs) and of acute myeloid leukemia (AML) cell lines. In an attempt to modulate the cellular metabolism for therapeutic intervention, we tested the following compounds that directly interfere with major metabolic or signaling pathways: dichloroacetate (DCA), a glycolysis inhibitor; aminooxyacetate (AOA)
2013
American Society of Hematology (ASH) 55th Annual Meeting
04 Pubblicazione in atti di convegno::04d Abstract in atti di convegno
Modulation of the glycolytic metabolism in acute myeloid leukemia cells / Mirabilii, Simone; Ricciardi, Maria Rosaria; Allegretti, Matteo; Licchetta, Roberto; M., Vincenzi; R., Nicolai; Foa, Roberto; Tafuri, Agostino. - In: BLOOD. - ISSN 0006-4971. - ELETTRONICO. - 122:(2013). (Intervento presentato al convegno American Society of Hematology (ASH) 55th Annual Meeting tenutosi a New Orleans, Louisiana, USA nel December 7 - 10, 2013).
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/542668
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