Recombinant erythropoietin (EPO) analogs [erythropoiesis-stimulating agents (ESA)] are clinically used to treat anemia in patients with cancer receiving chemotherapy. After clinical trials reporting increased adverse events and/or reduced survival in ESA-treated patients, concerns have been raised about the potential role of ESAs in promoting tumor progression, possibly through tumor cell stimulation. However, evidence is lacking on the ability of EPO to directly affect cancer stem-like cells, which are thought to be responsible for tumor progression and relapse. We found that breast cancer stem-like cells (BCSC) isolated from patient tumors express the EPO receptor and respond to EPO treatment with increased proliferation and self-renewal. Importantly, EPO stimulation increased BCSC resistance to chemotherapeutic agents and activated cellular pathways responsible for survival and drug resistance. Specifically, the Akt and ERK pathways were activated in BCSC at early time points follo

Erythropoietin activates cell survival pathways in breast cancer stem-like cells to protect them from chemotherapy / Todaro, M; Turdo, A; Bartucci, M; Iovino, F; Dattilo, R; Biffoni, Marco; Stassi, G; Federici, G; De Maria, R; Zeuner, A.. - In: CANCER RESEARCH. - ISSN 0008-5472. - STAMPA. - 73:(2013), pp. 6393-6400. [10.1158/0008-5472.CAN-13-0248]

Erythropoietin activates cell survival pathways in breast cancer stem-like cells to protect them from chemotherapy

BIFFONI, Marco;Federici G;
2013

Abstract

Recombinant erythropoietin (EPO) analogs [erythropoiesis-stimulating agents (ESA)] are clinically used to treat anemia in patients with cancer receiving chemotherapy. After clinical trials reporting increased adverse events and/or reduced survival in ESA-treated patients, concerns have been raised about the potential role of ESAs in promoting tumor progression, possibly through tumor cell stimulation. However, evidence is lacking on the ability of EPO to directly affect cancer stem-like cells, which are thought to be responsible for tumor progression and relapse. We found that breast cancer stem-like cells (BCSC) isolated from patient tumors express the EPO receptor and respond to EPO treatment with increased proliferation and self-renewal. Importantly, EPO stimulation increased BCSC resistance to chemotherapeutic agents and activated cellular pathways responsible for survival and drug resistance. Specifically, the Akt and ERK pathways were activated in BCSC at early time points follo
2013
RECOMBINANT-HUMAN-ERYTHROPOIETIN, STIMULATING AGENTS, EXPRESSION, MORTALITY, TRIALS, ANEMIA, ALPHA, ALDH1
01 Pubblicazione su rivista::01a Articolo in rivista
Erythropoietin activates cell survival pathways in breast cancer stem-like cells to protect them from chemotherapy / Todaro, M; Turdo, A; Bartucci, M; Iovino, F; Dattilo, R; Biffoni, Marco; Stassi, G; Federici, G; De Maria, R; Zeuner, A.. - In: CANCER RESEARCH. - ISSN 0008-5472. - STAMPA. - 73:(2013), pp. 6393-6400. [10.1158/0008-5472.CAN-13-0248]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/541946
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