Background. Endarterectomy (CEA) or stenting (CAS) of a stenotic carotid artery is currently undertaken to reduce stroke risk. In addition removal of the arterial narrowing has been hypothesized to improve cerebral hemodynamics and provide benefits in cognitive functions, by supposedly resolving a "hypoperfusion" condition. Methods. In this study we sought to test whether resolution of a carotid stenosis is followed by measurable changes in cognitive functions in 22 subjects with "asymptomatic" stenosis. Results. A main finding of the study was the statistically significant pre-post difference observed in the performance of phonological verbal fluency and Rey's 15-word immediate recall. Remarkably, there was a significant interaction between phonological verbal fluency performance and side of the carotid intervention, as the improvement in the verbal performance, a typical "lateralized" skill, was associated with resolution of the left carotid stenosis. Conclusion. The results reflect a substantial equivalence of the overall performance at the before- and after- CEA or CAS tests. In two domains, however, the postintervention performance resulted improved. The findings support the hypothesis that recanalization of a stenotic carotid could improve brain functions by resolving hypothetical "hypoperfusion" states, associated with the narrowing of the vessels. © 2013 Livio Picchetto et al.

Cognitive performance following carotid endarterectomy or stenting in asymptomatic patients with severe ICA stenosis / Picchetto, Livio; Gianfranco, Spalletta; Casolla, Barbara; Claudia, Cacciari; Cavallari, Michele; Fantozzi, Cristiano; Ciuffoli, Alessandro; Rasura, Maurizia; Francesca, Imperiale; Sette, Giuliano; Carlo, Caltagirone; Taurino, Maurizio; Orzi, Francesco. - In: CARDIOVASCULAR PSYCHIATRY AND NEUROLOGY. - ISSN 2090-0163. - ELETTRONICO. - 2013:(2013), pp. 1-6. [10.1155/2013/342571]

Cognitive performance following carotid endarterectomy or stenting in asymptomatic patients with severe ICA stenosis

PICCHETTO, LIVIO;CASOLLA, BARBARA;CAVALLARI, MICHELE;FANTOZZI, CRISTIANO;CIUFFOLI, ALESSANDRO;RASURA, Maurizia;SETTE, Giuliano;TAURINO, Maurizio;ORZI, Francesco
2013

Abstract

Background. Endarterectomy (CEA) or stenting (CAS) of a stenotic carotid artery is currently undertaken to reduce stroke risk. In addition removal of the arterial narrowing has been hypothesized to improve cerebral hemodynamics and provide benefits in cognitive functions, by supposedly resolving a "hypoperfusion" condition. Methods. In this study we sought to test whether resolution of a carotid stenosis is followed by measurable changes in cognitive functions in 22 subjects with "asymptomatic" stenosis. Results. A main finding of the study was the statistically significant pre-post difference observed in the performance of phonological verbal fluency and Rey's 15-word immediate recall. Remarkably, there was a significant interaction between phonological verbal fluency performance and side of the carotid intervention, as the improvement in the verbal performance, a typical "lateralized" skill, was associated with resolution of the left carotid stenosis. Conclusion. The results reflect a substantial equivalence of the overall performance at the before- and after- CEA or CAS tests. In two domains, however, the postintervention performance resulted improved. The findings support the hypothesis that recanalization of a stenotic carotid could improve brain functions by resolving hypothetical "hypoperfusion" states, associated with the narrowing of the vessels. © 2013 Livio Picchetto et al.
2013
Cardiology and Cardiovascular Medicine; Psychiatry and Mental Health; Neurology (clinical); Neurology
01 Pubblicazione su rivista::01a Articolo in rivista
Cognitive performance following carotid endarterectomy or stenting in asymptomatic patients with severe ICA stenosis / Picchetto, Livio; Gianfranco, Spalletta; Casolla, Barbara; Claudia, Cacciari; Cavallari, Michele; Fantozzi, Cristiano; Ciuffoli, Alessandro; Rasura, Maurizia; Francesca, Imperiale; Sette, Giuliano; Carlo, Caltagirone; Taurino, Maurizio; Orzi, Francesco. - In: CARDIOVASCULAR PSYCHIATRY AND NEUROLOGY. - ISSN 2090-0163. - ELETTRONICO. - 2013:(2013), pp. 1-6. [10.1155/2013/342571]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/541347
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