Full details as well as the study of the scope, limitations, and further elaboration of a straightforward approach to the synthesis of 2,5,7-trisubstituted benzo[b]furans from 2-bromo- and 2-chloro-6-iodo-4-substituted phenols through a consecutive copper- and/or palladium-catalyzed assembly and functionalization process is described. Functionalization at the C(7) position is carried out by Suzuki-Miyaura cross-coupling, alkynylation, alkenylation, and C-N bond forming reactions. A one-pot protocol for the synthesis of 2,5,7-trisubstituted benzo[b]furans is also reported. (C) 2012 Elsevier Ltd. All rights reserved.
Multisubstituted benzo[b]furans through a copper- and/or palladium-catalyzed assembly and functionalization process / Antonio, Arcadi; Federico, Blesi; Cacchi, Sandro; Fabrizi, Giancarlo; Goggiamani, Antonella; Fabio, Marinelli. - In: TETRAHEDRON. - ISSN 0040-4020. - STAMPA. - 69:7(2013), pp. 1857-1871. [10.1016/j.tet.2012.12.058]
Multisubstituted benzo[b]furans through a copper- and/or palladium-catalyzed assembly and functionalization process
CACCHI, Sandro;FABRIZI, Giancarlo;GOGGIAMANI, ANTONELLA;
2013
Abstract
Full details as well as the study of the scope, limitations, and further elaboration of a straightforward approach to the synthesis of 2,5,7-trisubstituted benzo[b]furans from 2-bromo- and 2-chloro-6-iodo-4-substituted phenols through a consecutive copper- and/or palladium-catalyzed assembly and functionalization process is described. Functionalization at the C(7) position is carried out by Suzuki-Miyaura cross-coupling, alkynylation, alkenylation, and C-N bond forming reactions. A one-pot protocol for the synthesis of 2,5,7-trisubstituted benzo[b]furans is also reported. (C) 2012 Elsevier Ltd. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
