Here we report a case of panhypopituitarism caused by pituitary Langerhans cell hystocitosis (LCH) in a 22-year-old woman affected by papillary thyroid carcinoma (PTC). Although several cases of the coexistence of PTC and LCH within thyroid tissue have been described in relative literature, in this case, the patient presented a unique suprasellar retrochiasmatic histocytosis localization which, to the best of our knowledge, had never been described before in association with PTC. Even if this aspect is not addressed in the present case report, it is worth noting that about 50\% of the patients affected either by LCH or PTC are characterized by activating mutations of the proto-oncogene BRAF. This, along with other clinical studies, may warrant further biomolecular large-scale case study investigations in order to evaluate a possible connection between the 2 conditions and shed light on the etiology of these diseases, which are still largely unknown.

Association between Pituitary Langerhans Cell Histiocytosis and Papillary Thyroid Carcinoma / Guarino, Salvatore; D. M., Giusti; A., Rubini; P., Favoriti; C., Fioravanti; DI MATTEO, Filippo Maria; D'Andrea, Vito; DE ANTONI, Enrico; Catania, Antonio. - In: CLINICAL MEDICINE INSIGHTS. CASE REPORTS. - ISSN 1179-5476. - STAMPA. - 6:(2013), pp. 197-200. [10.4137/CCRep.S13021]

Association between Pituitary Langerhans Cell Histiocytosis and Papillary Thyroid Carcinoma.

GUARINO, SALVATORE;DI MATTEO, Filippo Maria;D'ANDREA, Vito;DE ANTONI, Enrico;CATANIA, Antonio
2013

Abstract

Here we report a case of panhypopituitarism caused by pituitary Langerhans cell hystocitosis (LCH) in a 22-year-old woman affected by papillary thyroid carcinoma (PTC). Although several cases of the coexistence of PTC and LCH within thyroid tissue have been described in relative literature, in this case, the patient presented a unique suprasellar retrochiasmatic histocytosis localization which, to the best of our knowledge, had never been described before in association with PTC. Even if this aspect is not addressed in the present case report, it is worth noting that about 50\% of the patients affected either by LCH or PTC are characterized by activating mutations of the proto-oncogene BRAF. This, along with other clinical studies, may warrant further biomolecular large-scale case study investigations in order to evaluate a possible connection between the 2 conditions and shed light on the etiology of these diseases, which are still largely unknown.
2013
01 Pubblicazione su rivista::01a Articolo in rivista
Association between Pituitary Langerhans Cell Histiocytosis and Papillary Thyroid Carcinoma / Guarino, Salvatore; D. M., Giusti; A., Rubini; P., Favoriti; C., Fioravanti; DI MATTEO, Filippo Maria; D'Andrea, Vito; DE ANTONI, Enrico; Catania, Antonio. - In: CLINICAL MEDICINE INSIGHTS. CASE REPORTS. - ISSN 1179-5476. - STAMPA. - 6:(2013), pp. 197-200. [10.4137/CCRep.S13021]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/537242
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