Given the huge amount and great complexity of astrocyte functions in the maintenance of brain homeostasis, it is easily understood how alterations in their physiology may be involved in the pathogenesis of many, if not all, neurological disorders. This assumption is strongly supported by accumulated evidence produced in humans and in experimental models of pathology. Based on these considerations, it is reasonable to encourage studies aimed at improving the knowledge about the implicated mechanisms, and astroglial cells can be considered as the innovative target for new, and possibly more effective, drug therapies. (c) 2013 IUBMB Life, 65(12):957-961, 2013.
Role of astrocytes in major neurological disorders: The evidence and implications / Scuderi, Caterina; Stecca, Claudia; Aniello, Iacomino; Steardo, Luca. - In: IUBMB LIFE. - ISSN 1521-6543. - 65:12(2013), pp. 957-961. [10.1002/iub.1223]
Role of astrocytes in major neurological disorders: The evidence and implications
SCUDERI, CATERINA;STECCA, CLAUDIA;STEARDO, LUCA
2013
Abstract
Given the huge amount and great complexity of astrocyte functions in the maintenance of brain homeostasis, it is easily understood how alterations in their physiology may be involved in the pathogenesis of many, if not all, neurological disorders. This assumption is strongly supported by accumulated evidence produced in humans and in experimental models of pathology. Based on these considerations, it is reasonable to encourage studies aimed at improving the knowledge about the implicated mechanisms, and astroglial cells can be considered as the innovative target for new, and possibly more effective, drug therapies. (c) 2013 IUBMB Life, 65(12):957-961, 2013.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
