Osteoporosis is a bone metabolic disease characterized by a compromised skeletal fragility, leading to an increased risk of developing spontaneous and traumatic fractures. This disease is the consequence of an imbalance of the physiological process of bone turnover (or coupling), with the lost of the equilibrium between the activity of osteoblasts and osteoclasts. Therapy has been aimed mainly at the correction of the imbalance between bone resorption and bone formation, to protect skeletal integrity and reduce the risk of fractures. Thus, pharmacological treatments have been aimed at modulating the activity of bone cells.

New therapeutical horizons in the management of postmenopausal osteoporosis / Silvia, Migliaccio; Rachele, Fornari; Greco, Emanuela; Luigi Di, Luigi; Lenzi, Andrea. - In: AGING CLINICAL AND EXPERIMENTAL RESEARCH. - ISSN 1594-0667. - 25:1(2013), pp. S117-S119. [10.1007/s40520-013-0106-x]

New therapeutical horizons in the management of postmenopausal osteoporosis

Silvia Migliaccio;GRECO, EMANUELA;LENZI, Andrea
2013

Abstract

Osteoporosis is a bone metabolic disease characterized by a compromised skeletal fragility, leading to an increased risk of developing spontaneous and traumatic fractures. This disease is the consequence of an imbalance of the physiological process of bone turnover (or coupling), with the lost of the equilibrium between the activity of osteoblasts and osteoclasts. Therapy has been aimed mainly at the correction of the imbalance between bone resorption and bone formation, to protect skeletal integrity and reduce the risk of fractures. Thus, pharmacological treatments have been aimed at modulating the activity of bone cells.
2013
denosumab; teriparatide; osteoporosis; sclerostin; cathepsin k; therapies
01 Pubblicazione su rivista::01a Articolo in rivista
New therapeutical horizons in the management of postmenopausal osteoporosis / Silvia, Migliaccio; Rachele, Fornari; Greco, Emanuela; Luigi Di, Luigi; Lenzi, Andrea. - In: AGING CLINICAL AND EXPERIMENTAL RESEARCH. - ISSN 1594-0667. - 25:1(2013), pp. S117-S119. [10.1007/s40520-013-0106-x]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/535282
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