Genomes of multicellular organisms are characterized by the pervasive expression of different types of non-coding RNAs (ncRNAs). Long ncRNAs (lncRNAs) belong to a novel heterogeneous class of ncRNAs that includes thousands of different species. lncRNAs have crucial roles in gene expression control during both developmental and differentiation processes, and the number of lncRNA species increases in genomes of developmentally complex organisms, which highlights the importance of RNA-based levels of control in the evolution of multicellular organisms. In this Review, we describe the function of lncRNAs in developmental processes, such as in dosage compensation, genomic imprinting, cell differentiation and organogenesis, with a particular emphasis on mammalian development. © 2014 Macmillan Publishers Limited.

Long non-coding RNAs: New players in cell differentiation and development / Fatica, Alessandro; Bozzoni, Irene. - In: NATURE REVIEWS GENETICS. - ISSN 1471-0056. - STAMPA. - 15:1(2014), pp. 7-21. [10.1038/nrg3606]

Long non-coding RNAs: New players in cell differentiation and development

FATICA, Alessandro;BOZZONI, Irene
2014

Abstract

Genomes of multicellular organisms are characterized by the pervasive expression of different types of non-coding RNAs (ncRNAs). Long ncRNAs (lncRNAs) belong to a novel heterogeneous class of ncRNAs that includes thousands of different species. lncRNAs have crucial roles in gene expression control during both developmental and differentiation processes, and the number of lncRNA species increases in genomes of developmentally complex organisms, which highlights the importance of RNA-based levels of control in the evolution of multicellular organisms. In this Review, we describe the function of lncRNAs in developmental processes, such as in dosage compensation, genomic imprinting, cell differentiation and organogenesis, with a particular emphasis on mammalian development. © 2014 Macmillan Publishers Limited.
2014
cell differentiation; development; lncrna
01 Pubblicazione su rivista::01a Articolo in rivista
Long non-coding RNAs: New players in cell differentiation and development / Fatica, Alessandro; Bozzoni, Irene. - In: NATURE REVIEWS GENETICS. - ISSN 1471-0056. - STAMPA. - 15:1(2014), pp. 7-21. [10.1038/nrg3606]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/535098
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