Lymph node metastases are responsible for shorter survival in oral squamous cell carcinoma (OSCC). The aim of the present study was to assess the node metastasis frequency and survival according to the node metastasis features in 121 neck dissections (NDs) performed for OSCC, identifying evidence-based correlations and contrasts with previous literature. The retrospective study involved 121 patients affected by OSCC who had undergone modified radical ND (MRND) for therapeutic, elective reasons or after intraoperative positivity to metastasis of sentinel lymph nodes (SLN+). Node metastasis frequency and behaviour (typical vs. atypical) and their number and distribution according to pre-surgical cTNM cancer staging were considered and overall survival Kaplan-Meier curves were calculated for each group in order to compare mortality according to ND type (elective, therapeutic, after SLN+), lymph node metastatic pattern (typical or atypical), size (micrometastasis vs. macrometastasis) and number. Results showed statistically significant different overall survival according to pre-surgical staging, number of lymph nodes harvested and intent to surgery. Sentinel lymph node resulted in the sole positive node affected by metastasis in small cT1- cT2/cN0 OSCC and an ND subsequent to its positivity during intraoperative assessment may be considered an overtreatment.

Prognostic implications of node metastatic features in OSCC: a retrospective study on 121 neck dissections / M., Contaldo; A., Di Napoli; G., Pannone; R., Franco; F., Ionna; A., Feola; Alfredo De, Rosa; A., Santoro; C., Sbordone; F., Longo; D., Pasquali; C., Loreto; F., Ricciardiello; G., Esposito; L., D'Angelo; A., Itro; P., Bufo; Tombolini, Vincenzo; R., Serpico; M., Di Domenico. - In: ONCOLOGY REPORTS. - ISSN 1021-335X. - ELETTRONICO. - 30:6(2013), pp. 2697-2704. [10.3892/or.2013.2779]

Prognostic implications of node metastatic features in OSCC: a retrospective study on 121 neck dissections.

TOMBOLINI, Vincenzo;
2013

Abstract

Lymph node metastases are responsible for shorter survival in oral squamous cell carcinoma (OSCC). The aim of the present study was to assess the node metastasis frequency and survival according to the node metastasis features in 121 neck dissections (NDs) performed for OSCC, identifying evidence-based correlations and contrasts with previous literature. The retrospective study involved 121 patients affected by OSCC who had undergone modified radical ND (MRND) for therapeutic, elective reasons or after intraoperative positivity to metastasis of sentinel lymph nodes (SLN+). Node metastasis frequency and behaviour (typical vs. atypical) and their number and distribution according to pre-surgical cTNM cancer staging were considered and overall survival Kaplan-Meier curves were calculated for each group in order to compare mortality according to ND type (elective, therapeutic, after SLN+), lymph node metastatic pattern (typical or atypical), size (micrometastasis vs. macrometastasis) and number. Results showed statistically significant different overall survival according to pre-surgical staging, number of lymph nodes harvested and intent to surgery. Sentinel lymph node resulted in the sole positive node affected by metastasis in small cT1- cT2/cN0 OSCC and an ND subsequent to its positivity during intraoperative assessment may be considered an overtreatment.
2013
01 Pubblicazione su rivista::01a Articolo in rivista
Prognostic implications of node metastatic features in OSCC: a retrospective study on 121 neck dissections / M., Contaldo; A., Di Napoli; G., Pannone; R., Franco; F., Ionna; A., Feola; Alfredo De, Rosa; A., Santoro; C., Sbordone; F., Longo; D., Pasquali; C., Loreto; F., Ricciardiello; G., Esposito; L., D'Angelo; A., Itro; P., Bufo; Tombolini, Vincenzo; R., Serpico; M., Di Domenico. - In: ONCOLOGY REPORTS. - ISSN 1021-335X. - ELETTRONICO. - 30:6(2013), pp. 2697-2704. [10.3892/or.2013.2779]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/531181
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 29
  • ???jsp.display-item.citation.isi??? 27
social impact