Alzheimer's disease (AD) is the most common cause of dementia and, with an aging population, poses a huge public health problem. Although a small per cent is caused by single gene changes, most AD is sporadic and unexplained. Of many modifying factors, changes in brain cholesterol homeostasis are the best studied. We present a review of the role of altered cholesterol metabolism and hypercholesterolemia in APP processing and Aβ generation. We also provide an overview of the potential pharmacological modulation of cholesterol homeostasis in the brain by cholesterol-lowering agents and β- cyclodextrins. Copyright © by BIOLIFE, s.a.s.

Cholesterol metabolism-associated molecules in late onset Alzheimer disease / Fiorenza, Maria Teresa; Andrea, Dardis; Canterini, Sonia; Robert Porter, Erickson. - In: JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS. - ISSN 0393-974X. - STAMPA. - 27:2 SUPPL.(2013), pp. 23-35.

Cholesterol metabolism-associated molecules in late onset Alzheimer disease

FIORENZA, Maria Teresa;CANTERINI, Sonia;
2013

Abstract

Alzheimer's disease (AD) is the most common cause of dementia and, with an aging population, poses a huge public health problem. Although a small per cent is caused by single gene changes, most AD is sporadic and unexplained. Of many modifying factors, changes in brain cholesterol homeostasis are the best studied. We present a review of the role of altered cholesterol metabolism and hypercholesterolemia in APP processing and Aβ generation. We also provide an overview of the potential pharmacological modulation of cholesterol homeostasis in the brain by cholesterol-lowering agents and β- cyclodextrins. Copyright © by BIOLIFE, s.a.s.
2013
load susceptibility genes; β-cyclodextrins; niemann-pick c1
01 Pubblicazione su rivista::01a Articolo in rivista
Cholesterol metabolism-associated molecules in late onset Alzheimer disease / Fiorenza, Maria Teresa; Andrea, Dardis; Canterini, Sonia; Robert Porter, Erickson. - In: JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS. - ISSN 0393-974X. - STAMPA. - 27:2 SUPPL.(2013), pp. 23-35.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/530642
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