Biliary strictures (BS) remain a significant problem following liver transplantation (LT), representing an important cause of morbidity. The purpose of this follow-up study was to evaluate the incidence and risk factors associated with BS after LT. From 2001 to 2009, 244 consecutive patients underwent LT at our center. Multiple donor and recipient variables were collected for each patient. Exclusion criteria were hepaticojejunostomy, living-donor LT, and follow-up less than threemonths. We reviewed 177 patients, all of whom underwent an end-to-end choledochocholedochostomy and T-tube placement. BS occurred in 23% of patients. Multivariate analysis revealed that graft macrovesicular steatosis >25% (p=0.05, OR 3.38) and time of T-tube removal less than six months (p=0.02, OR 2.53) were independent risk factors for BS. Biliary strictures did not affect patient and graft survival. Donor macrovesicular steatosis represents a risk factor for BS, contributing to liver damage through a reduction in hepatic blood flow. Time of T-tube removal seems to play a role in the development of BS, although it is unclear whether it represents the cause or the consequence of the development of BS.

Graft macrosteatosis and time of T-tube removal as risk factors for biliary strictures after liver transplantation / Lattanzi, Barbara; Lai, Quirino; Guglielmo, Nicola; Giannelli, Valerio; Merli, Manuela; Giusto, Michela; Melandro, Fabio; GINANNI CORRADINI, Stefano; Mennini, Gianluca; Berloco, Pasquale Bartolomeo; Rossi, Massimo. - In: CLINICAL TRANSPLANTATION. - ISSN 0902-0063. - STAMPA. - 27:3(2013), pp. E332-E338. [10.1111/ctr.12124]

Graft macrosteatosis and time of T-tube removal as risk factors for biliary strictures after liver transplantation

LATTANZI, BARBARA;LAI, QUIRINO;GUGLIELMO, NICOLA;GIANNELLI, VALERIO;MERLI, Manuela;GIUSTO, MICHELA;MELANDRO, FABIO;GINANNI CORRADINI, Stefano;MENNINI, Gianluca;BERLOCO, Pasquale Bartolomeo;ROSSI, MASSIMO
2013

Abstract

Biliary strictures (BS) remain a significant problem following liver transplantation (LT), representing an important cause of morbidity. The purpose of this follow-up study was to evaluate the incidence and risk factors associated with BS after LT. From 2001 to 2009, 244 consecutive patients underwent LT at our center. Multiple donor and recipient variables were collected for each patient. Exclusion criteria were hepaticojejunostomy, living-donor LT, and follow-up less than threemonths. We reviewed 177 patients, all of whom underwent an end-to-end choledochocholedochostomy and T-tube placement. BS occurred in 23% of patients. Multivariate analysis revealed that graft macrovesicular steatosis >25% (p=0.05, OR 3.38) and time of T-tube removal less than six months (p=0.02, OR 2.53) were independent risk factors for BS. Biliary strictures did not affect patient and graft survival. Donor macrovesicular steatosis represents a risk factor for BS, contributing to liver damage through a reduction in hepatic blood flow. Time of T-tube removal seems to play a role in the development of BS, although it is unclear whether it represents the cause or the consequence of the development of BS.
2013
macrovesicular steatosis; liver transplantation; steatosis; biliary strictures; t-tube
01 Pubblicazione su rivista::01a Articolo in rivista
Graft macrosteatosis and time of T-tube removal as risk factors for biliary strictures after liver transplantation / Lattanzi, Barbara; Lai, Quirino; Guglielmo, Nicola; Giannelli, Valerio; Merli, Manuela; Giusto, Michela; Melandro, Fabio; GINANNI CORRADINI, Stefano; Mennini, Gianluca; Berloco, Pasquale Bartolomeo; Rossi, Massimo. - In: CLINICAL TRANSPLANTATION. - ISSN 0902-0063. - STAMPA. - 27:3(2013), pp. E332-E338. [10.1111/ctr.12124]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/529705
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