The Drosophila effete gene encodes an extremely conserved class I E2 ubiquitin-conjugating enzyme. Growing evidence indicates that Eff is involved in many cellular processes including eye development, maintenance of female germline stem cells, and regulation of apoptosis. Eff is also a major component of Drosophila chromatin and it is particularly enriched in chromatin with repressive properties. In addition, Eff is required for telomere protection and to prevent telomere fusion. Consistent with its multiple roles in chromatin maintenance, Eff is also one of the rare factors that modulate both telomere-induced and heterochromatin-induced position effect variegation.

Effete, an E2 ubiquitin-conjugating enzyme with multiple roles in Drosophila development and chromatin organization / Cipressa, Francesca; Cenci, Giovanni. - In: FLY. - ISSN 1933-6934. - STAMPA. - 7:4(2013), pp. 256-262. [10.4161/fly.26567]

Effete, an E2 ubiquitin-conjugating enzyme with multiple roles in Drosophila development and chromatin organization

CIPRESSA, FRANCESCA;CENCI, GIOVANNI
2013

Abstract

The Drosophila effete gene encodes an extremely conserved class I E2 ubiquitin-conjugating enzyme. Growing evidence indicates that Eff is involved in many cellular processes including eye development, maintenance of female germline stem cells, and regulation of apoptosis. Eff is also a major component of Drosophila chromatin and it is particularly enriched in chromatin with repressive properties. In addition, Eff is required for telomere protection and to prevent telomere fusion. Consistent with its multiple roles in chromatin maintenance, Eff is also one of the rare factors that modulate both telomere-induced and heterochromatin-induced position effect variegation.
2013
tpe; effete; e2 enzyme; pev; chromatin organization; ubcd1
01 Pubblicazione su rivista::01a Articolo in rivista
Effete, an E2 ubiquitin-conjugating enzyme with multiple roles in Drosophila development and chromatin organization / Cipressa, Francesca; Cenci, Giovanni. - In: FLY. - ISSN 1933-6934. - STAMPA. - 7:4(2013), pp. 256-262. [10.4161/fly.26567]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/525838
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