The C-type lectin MGL is a pathogen recognition receptor, expressed by dendritic cells (DCs) and macrophages (Ms), able to bind GalNAc (Tn)- carrying structures. This receptor also recogni- zed Tn-TAAs that were internalized, processed and presented by DCs to T cells and it acted as an adjuvant on DCs, highlighting its possible ap- plication in anti-cancer vaccination. In this work, we found that this receptor present a seasonal modulation: its expression is higher in winter rather than in summer. The percentage of MGL+ donors displayed a negative trend that dropped to 33% during the summer and increased up to 100% in winter. This modulation could be also ascribed to the circa-annual variation of gluco- corticoids, in fact MGL is up-regulated in pres- ence of dexamethasone in vitro. The seasonal variation of this receptor could be an important point in the field of tumor vaccination strategies.
The C-type lectin MGL is a pathogen recognition receptor, expressed by dendritic cells (DCs) and macrophages (Ms), able to bind GalNAc (Tn)- carrying structures. This receptor also recogni- zed Tn-TAAs that were internalized, processed and presented by DCs to T cells and it acted as an adjuvant on DCs, highlighting its possible ap- plication in anti-cancer vaccination. In this work, we found that this receptor present a seasonal modulation: its expression is higher in winter rather than in summer. The percentage of MGL+ donors displayed a negative trend that dropped to 33% during the summer and increased up to 100% in winter. This modulation could be also ascribed to the circa-annual variation of gluco- corticoids, in fact MGL is up-regulated in pres- ence of dexamethasone in vitro. The seasonal variation of this receptor could be an important point in the field of tumor vaccination strategies.
Seasonal modulation of the C-type lectin MGL on human DCs / Zizzari, ILARIA GRAZIA; Napoletano, Chiara; Rughetti, Aurelia; RAHIMI KOSHKAKI, Hassan; Nuti, Marianna. - In: OPEN JOURNAL OF IMMUNOLOGY. - ISSN 2162-4526. - ELETTRONICO. - 03:04(2013), pp. 218-220. [10.4236/oji.2013.34027]
Seasonal modulation of the C-type lectin MGL on human DCs
ZIZZARI, ILARIA GRAZIA;NAPOLETANO, Chiara;RUGHETTI, Aurelia;RAHIMI KOSHKAKI, HASSAN;NUTI, Marianna
2013
Abstract
The C-type lectin MGL is a pathogen recognition receptor, expressed by dendritic cells (DCs) and macrophages (Ms), able to bind GalNAc (Tn)- carrying structures. This receptor also recogni- zed Tn-TAAs that were internalized, processed and presented by DCs to T cells and it acted as an adjuvant on DCs, highlighting its possible ap- plication in anti-cancer vaccination. In this work, we found that this receptor present a seasonal modulation: its expression is higher in winter rather than in summer. The percentage of MGL+ donors displayed a negative trend that dropped to 33% during the summer and increased up to 100% in winter. This modulation could be also ascribed to the circa-annual variation of gluco- corticoids, in fact MGL is up-regulated in pres- ence of dexamethasone in vitro. The seasonal variation of this receptor could be an important point in the field of tumor vaccination strategies.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
