Discovery and optimization of pyrazoline derivatives as promising monoamine oxidase inhibitors

Secci, Daniela; Carradori, Simone; Bolasco, Adriana; Bizzarri, Bruna; D'Ascenzio, Melissa; Maccioni, E.

doi:10.2174/1568026611212200009

Among different heterocyclic chemotypes incorporating two nitrogen atoms, pyrazolines could be considered a valid pharmacophore for the synthesis of selective monoamine oxidase (MAO) inhibitors because they were developed by the cyclization of the early hydrazine derivatives such as isocarboxazid. Substituted pyrazolines, decorated with different functional groups, are important lead compounds endowed with a large amount of biological activities. As a matter of this, most of them were also evaluated as dual inhibitors with a synergistic action towards different classes of enzymes (ciclooxygenase, acetylcholinesterase, butyrylcholinesterase). Moreover due to the direct correlation with the recognized MAO inhibition, this scaffold displayed antidepressant and anticonvulsant properties in animal models.

Discovery and optimization of pyrazoline derivatives as promising monoamine oxidase inhibitors / Secci, Daniela; Carradori, Simone; Bolasco, Adriana; Bizzarri, Bruna; D'Ascenzio, Melissa; E., Maccioni. - In: CURRENT TOPICS IN MEDICINAL CHEMISTRY. - ISSN 1568-0266. - STAMPA. - 12:20(2012), pp. 2240-2257. [10.2174/1568026611212200009]

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Titolo:	Discovery and optimization of pyrazoline derivatives as promising monoamine oxidase inhibitors
Autori:	SECCI, DANIELA CARRADORI, Simone BOLASCO, Adriana BIZZARRI, Bruna D'ASCENZIO, MELISSA E. Maccioni mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2012
Rivista:	CURRENT TOPICS IN MEDICINAL CHEMISTRY
Citazione:	Discovery and optimization of pyrazoline derivatives as promising monoamine oxidase inhibitors / Secci, Daniela; Carradori, Simone; Bolasco, Adriana; Bizzarri, Bruna; D'Ascenzio, Melissa; E., Maccioni. - In: CURRENT TOPICS IN MEDICINAL CHEMISTRY. - ISSN 1568-0266. - STAMPA. - 12:20(2012), pp. 2240-2257. [10.2174/1568026611212200009]
Handle:	http://hdl.handle.net/11573/525670
Appartiene alla tipologia:	01a Articolo in rivista

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