Sunitinib malate (SU11248) is a multitarget oral tyrosine kinase receptor (RTKs) inhibitor which was approved by FDA in renal cells carcinoma (RCC) and imatinib-resistant or imatinib-intollerant gastrointestinal stromal tumour (GIST). Sunitinib is able to inhibit RTKs such as receptors for platelet-derived growth factor (PDGF-R alpha and beta) and for vascular endothelial growth factor (VEGFRs). It is able to inhibit KIT receptor, colony stimulating factor type 1 receptor (CSF-1R), glial cell line neutrophic factor receptor (RET), fms-like tyrosine kinase receptor-3 (FLT-3 or CD135), signal transducer and activator of transcription 3 (STAT3) and AKT (protein kinase B) in tumour cells. Many sunitinib targets play important roles in growth and survival of human breast cancer (BC). The "rationale" of sunitinib in BC (with or without others antiagiogenetic therapy) is its ability to block simultaneously intracellular portion of RTKs inhibiting many downstream signals. We overviewed the most relevant studies concerning sunitinib in metastatic BC. Clin Ter 2010; 161(5):475-482

New perspectives: role of Sunitinib in Breast Cancer / Fratto, M. e.; Imperatori, M.; Vincenzi, B.; Tomao, Federica; Santini, D.; Tonini, G.. - In: LA CLINICA TERAPEUTICA. - ISSN 0009-9074. - STAMPA. - 161:5(2010), pp. 475-482.

New perspectives: role of Sunitinib in Breast Cancer

TOMAO, FEDERICA;D. Santini;
2010

Abstract

Sunitinib malate (SU11248) is a multitarget oral tyrosine kinase receptor (RTKs) inhibitor which was approved by FDA in renal cells carcinoma (RCC) and imatinib-resistant or imatinib-intollerant gastrointestinal stromal tumour (GIST). Sunitinib is able to inhibit RTKs such as receptors for platelet-derived growth factor (PDGF-R alpha and beta) and for vascular endothelial growth factor (VEGFRs). It is able to inhibit KIT receptor, colony stimulating factor type 1 receptor (CSF-1R), glial cell line neutrophic factor receptor (RET), fms-like tyrosine kinase receptor-3 (FLT-3 or CD135), signal transducer and activator of transcription 3 (STAT3) and AKT (protein kinase B) in tumour cells. Many sunitinib targets play important roles in growth and survival of human breast cancer (BC). The "rationale" of sunitinib in BC (with or without others antiagiogenetic therapy) is its ability to block simultaneously intracellular portion of RTKs inhibiting many downstream signals. We overviewed the most relevant studies concerning sunitinib in metastatic BC. Clin Ter 2010; 161(5):475-482
2010
sunitinib; breast cancer; preclinical evidences; target therapy; angiogenesis; clinical trials
01 Pubblicazione su rivista::01a Articolo in rivista
New perspectives: role of Sunitinib in Breast Cancer / Fratto, M. e.; Imperatori, M.; Vincenzi, B.; Tomao, Federica; Santini, D.; Tonini, G.. - In: LA CLINICA TERAPEUTICA. - ISSN 0009-9074. - STAMPA. - 161:5(2010), pp. 475-482.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/524960
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