A challenging asymmetric reaction (aza-Michael addition of imides to enones) has been optimized through an integrated approach involving the synthesis of a family of organocatalysts, multiple catalysis (usage of additives), and finally with rational exploration of the chemical space by the application of the experiment design.
Enantioselective Aza-Michael Addition of Imides by Using an Integrated Strategy Involving the Synthesis of a Family of Multifunctional Catalysts, Usage of Multiple Catalysis, and Rational Design of Experiment / Silvi, M., Renzi, P., Rosato, D., Margarita, C., Vecchioni, A., Bordacchini, I., Morra, D., Nicolosi, A., Cari, R., Sciubba, F., Scarpino Schietroma, D.M., Bella, M.. - In: CHEMISTRY-A EUROPEAN JOURNAL. - ISSN 0947-6539. - STAMPA. - 19:30(2013), pp. 9973-9978. [10.1002/chem.201301493]
Enantioselective Aza-Michael Addition of Imides by Using an Integrated Strategy Involving the Synthesis of a Family of Multifunctional Catalysts, Usage of Multiple Catalysis, and Rational Design of Experiment
Polyssena Renzi;Cristiana Margarita;Fabio Sciubba;Daniele Maria Scarpino Schietroma;Marco Bella
2013
Abstract
A challenging asymmetric reaction (aza-Michael addition of imides to enones) has been optimized through an integrated approach involving the synthesis of a family of organocatalysts, multiple catalysis (usage of additives), and finally with rational exploration of the chemical space by the application of the experiment design.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
