We report a case of an isolated hepatic neoplasia which originated in a site of the liver previously affected by radiation induced liver disease (RILD) in a patient resected for gastric cancer and referred to us for high serum alpha-fetoprotein (AFP) levels. This case challenged us in distiguishing, even histologically, between primary liver cancer and AFP producing gastric cancer metastasis. Only a panel of immunohistochemical markers allowed the definitive diagnosis of liver metastasis of endodermal stem cell-derived and AFP producing gastric cancer. We discuss the criteria for a differential diagnosis, as well as the possible link between RILD and emergence of liver neoplasia.

An isolate alpha-fetoprotein producing gastric cancer liver metastasis emerged in a patient previously affected by radiation induced liver disease / Cardinale, Vincenzo; DE FILIPPIS, Gianmaria; Corsi, Alessandro; Rossi, Michele; Catalano, Carlo; Bianco, Paolo; DE SANTIS, Adriano; Alvaro, Domenico. - In: WORLD JOURNAL OF HEPATOLOGY. - ISSN 1948-5182. - STAMPA. - 5:7(2013), pp. 398-403. [10.4254/wjh.v5.i7.398]

An isolate alpha-fetoprotein producing gastric cancer liver metastasis emerged in a patient previously affected by radiation induced liver disease

CARDINALE, VINCENZO;DE FILIPPIS, GIANMARIA;CORSI, ALESSANDRO;ROSSI, Michele;CATALANO, Carlo;BIANCO, Paolo;DE SANTIS, Adriano;ALVARO, Domenico
2013

Abstract

We report a case of an isolated hepatic neoplasia which originated in a site of the liver previously affected by radiation induced liver disease (RILD) in a patient resected for gastric cancer and referred to us for high serum alpha-fetoprotein (AFP) levels. This case challenged us in distiguishing, even histologically, between primary liver cancer and AFP producing gastric cancer metastasis. Only a panel of immunohistochemical markers allowed the definitive diagnosis of liver metastasis of endodermal stem cell-derived and AFP producing gastric cancer. We discuss the criteria for a differential diagnosis, as well as the possible link between RILD and emergence of liver neoplasia.
radiationinduced liver disease; liver metastasization; alpha-fetoprotein producing gastric cancer; radiation induced liver disease; hepatoid adenocarcinoma
01 Pubblicazione su rivista::01a Articolo in rivista
An isolate alpha-fetoprotein producing gastric cancer liver metastasis emerged in a patient previously affected by radiation induced liver disease / Cardinale, Vincenzo; DE FILIPPIS, Gianmaria; Corsi, Alessandro; Rossi, Michele; Catalano, Carlo; Bianco, Paolo; DE SANTIS, Adriano; Alvaro, Domenico. - In: WORLD JOURNAL OF HEPATOLOGY. - ISSN 1948-5182. - STAMPA. - 5:7(2013), pp. 398-403. [10.4254/wjh.v5.i7.398]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/523510
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