The synthesis, characterization, and luminescent properties of a series of 5,5'-X-substituted salophen ligands, X= OCH3, Br, and NO2, and the corresponding Zn(II) complexes are reported here. Their biological activity has been analyzed and related to the different Lewis acid character of the complexes. In vitro studies (AFM and absorption and emission titrations) show that the strongest interaction with free plasmid DNA is observed for 5,5'-dinitro-substituted Zinc-salophen complex 3b. Semiempirical theoretical calculations together with redox potential measurements suggest that this might be interpreted as a direct consequence of this compound having the hardest Lewis acid character. Cellular uptake and cytotoxicity studies undertaken with these metal complexes show that they enter the cells but are not cytotoxic.

Substituent Effects on the Biological Properties of Zn-Salophen Complexes / Giannicchi, Ilaria; Rosa, Brissos; David, Ramos; Joaquin De, Lapuente; Joao Carlos, Lima; DALLA CORT, Antonella; Laura, Rodriguez. - In: INORGANIC CHEMISTRY. - ISSN 0020-1669. - STAMPA. - 52:16(2013), pp. 9245-9253. [10.1021/ic4004356]

Substituent Effects on the Biological Properties of Zn-Salophen Complexes

GIANNICCHI, ILARIA;DALLA CORT, Antonella;
2013

Abstract

The synthesis, characterization, and luminescent properties of a series of 5,5'-X-substituted salophen ligands, X= OCH3, Br, and NO2, and the corresponding Zn(II) complexes are reported here. Their biological activity has been analyzed and related to the different Lewis acid character of the complexes. In vitro studies (AFM and absorption and emission titrations) show that the strongest interaction with free plasmid DNA is observed for 5,5'-dinitro-substituted Zinc-salophen complex 3b. Semiempirical theoretical calculations together with redox potential measurements suggest that this might be interpreted as a direct consequence of this compound having the hardest Lewis acid character. Cellular uptake and cytotoxicity studies undertaken with these metal complexes show that they enter the cells but are not cytotoxic.
2013
01 Pubblicazione su rivista::01a Articolo in rivista
Substituent Effects on the Biological Properties of Zn-Salophen Complexes / Giannicchi, Ilaria; Rosa, Brissos; David, Ramos; Joaquin De, Lapuente; Joao Carlos, Lima; DALLA CORT, Antonella; Laura, Rodriguez. - In: INORGANIC CHEMISTRY. - ISSN 0020-1669. - STAMPA. - 52:16(2013), pp. 9245-9253. [10.1021/ic4004356]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/521784
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 50
  • ???jsp.display-item.citation.isi??? 47
social impact