Hypertension and cardiomyopathies share maladaptive changes of cardiac morphology, eventually leading to heart failure. These include left ventricular hypertrophy (LVH), myocardial fibrosis, and structural remodeling of coronary microcirculation, which is the morphologic hallmark of coronary microvascular dysfunction. To pinpoint the complex molecular mechanisms and pathways underlying LVH-associated cardiac remodeling independent of blood pressure effects, we employed gene network approaches to the rat heart. We used the Spontaneously Hypertensive Rat model showing many features of human hypertensive cardiomyopathy, for which we collected histological and histomorphometric data of the heart and coronary vasculature, and genome-wide cardiac gene expression. Here, we provide a large catalogue of gene co-expression networks in the heart that are significantly associated with quantitative variation in LVH, microvascular remodeling, and fibrosis-related traits. Many of these networks were significantly conserved to human idiopathic and/or ischemic cardiomyopathy patients, suggesting a potential role for these co-expressed genes in human heart disease.

Transcriptional Network Analysis for the Regulation of Left Ventricular Hypertrophy and Microvascular Remodeling / Aida Moreno, Moral; Mancini, Massimiliano; D'Amati, Giulia; Paolo, Camici; Enrico, Petretto. - In: JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH. - ISSN 1937-5387. - STAMPA. - 6:6(2013), pp. 931-944. [10.1007/s12265-013-9504-x]

Transcriptional Network Analysis for the Regulation of Left Ventricular Hypertrophy and Microvascular Remodeling

MANCINI, MASSIMILIANO;D'AMATI, Giulia;
2013

Abstract

Hypertension and cardiomyopathies share maladaptive changes of cardiac morphology, eventually leading to heart failure. These include left ventricular hypertrophy (LVH), myocardial fibrosis, and structural remodeling of coronary microcirculation, which is the morphologic hallmark of coronary microvascular dysfunction. To pinpoint the complex molecular mechanisms and pathways underlying LVH-associated cardiac remodeling independent of blood pressure effects, we employed gene network approaches to the rat heart. We used the Spontaneously Hypertensive Rat model showing many features of human hypertensive cardiomyopathy, for which we collected histological and histomorphometric data of the heart and coronary vasculature, and genome-wide cardiac gene expression. Here, we provide a large catalogue of gene co-expression networks in the heart that are significantly associated with quantitative variation in LVH, microvascular remodeling, and fibrosis-related traits. Many of these networks were significantly conserved to human idiopathic and/or ischemic cardiomyopathy patients, suggesting a potential role for these co-expressed genes in human heart disease.
2013
gene regulatory networks; spontaneously hypertensive rat (shr); coronary microvascular remodeling; cardiac fibrosis; left ventricular hypertrophy
01 Pubblicazione su rivista::01a Articolo in rivista
Transcriptional Network Analysis for the Regulation of Left Ventricular Hypertrophy and Microvascular Remodeling / Aida Moreno, Moral; Mancini, Massimiliano; D'Amati, Giulia; Paolo, Camici; Enrico, Petretto. - In: JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH. - ISSN 1937-5387. - STAMPA. - 6:6(2013), pp. 931-944. [10.1007/s12265-013-9504-x]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/521632
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