Acute lymphoblastic leukemia shows marked differences in outcome between children and adults. Since there is limited information on the distribution of clinico-biologic variables in different age cohorts, we analyzed 5202 ALL patients enrolled in the Italian multicenter AIEOP and GIMEMA protocols and stratified them in 9 age cohorts. The highest prevalence of ALL was observed in children, although a second peak was recorded from the 4th decade onwards. Interestingly, the lowest incidence was found in females between 14-40 years, suggesting a protective impact of fertility. Immunophenotypic characterization showed a B-lineage in 85.8% of patients: a pro-B stage, associated to MLL/AF4 positivity, was more frequent in patients between 10-50 years. A T-lineage (14.2%) was rare among small children and increased in 10-40 years patients. The BCR/ABL1 rearrangement increased progressively with age, starting from the 10-14 cohort and impacting for 52.7% of cases in the 6th decade. Similarly, the MLL/AF4 rearrangement constantly increased up to the 5th decade, while the ETV6/RUNX1 rearrangement disappeared from the age of 30 onwards. This study shows that adolescents and young adults are characterized by a male prevalence, greater T-lineage acute lymphoblastic leuekmia percentage, an increase of poor prognostic molecular markers with aging compared to children, and conclusively quantifies the progressive increase with age of BCR/ABL+ patients, potentially manageable by targeted therapies.

Clinico-biologic features of 5202 acute lymphoblastic leukemia patients enrolled in the Italian AIEOP and GIMEMA Protocols and stratified in age-cohorts / Chiaretti, Sabina; Vitale, A; Cazzaniga, G; Orlando, Sm; Silvestri, D; Fazi, P; Valsecchi, Mg; Elia, Loredana; Testi, Anna Maria; Mancini, Francesca; Conter, V; Te Kronnie, G; Ferrara, F; Di Raimondo, F; Tedeschi, A; Fioritoni, G; Fabbiano, F; Meloni, Giovanna; Specchia, G; Pizzolo, G; Mandelli, Franco; Guarini, Anna; Basso, G; Biondi, A; Foa, Roberto. - In: HAEMATOLOGICA. - ISSN 0390-6078. - 98:11(2013), pp. 1702-1710. [10.3324/haematol.2012.080432]

Clinico-biologic features of 5202 acute lymphoblastic leukemia patients enrolled in the Italian AIEOP and GIMEMA Protocols and stratified in age-cohorts.

CHIARETTI, sabina;ELIA, LOREDANA;TESTI, Anna Maria;MANCINI, Francesca;MELONI, Giovanna;MANDELLI, Franco;GUARINI, Anna;FOA, Roberto
2013

Abstract

Acute lymphoblastic leukemia shows marked differences in outcome between children and adults. Since there is limited information on the distribution of clinico-biologic variables in different age cohorts, we analyzed 5202 ALL patients enrolled in the Italian multicenter AIEOP and GIMEMA protocols and stratified them in 9 age cohorts. The highest prevalence of ALL was observed in children, although a second peak was recorded from the 4th decade onwards. Interestingly, the lowest incidence was found in females between 14-40 years, suggesting a protective impact of fertility. Immunophenotypic characterization showed a B-lineage in 85.8% of patients: a pro-B stage, associated to MLL/AF4 positivity, was more frequent in patients between 10-50 years. A T-lineage (14.2%) was rare among small children and increased in 10-40 years patients. The BCR/ABL1 rearrangement increased progressively with age, starting from the 10-14 cohort and impacting for 52.7% of cases in the 6th decade. Similarly, the MLL/AF4 rearrangement constantly increased up to the 5th decade, while the ETV6/RUNX1 rearrangement disappeared from the age of 30 onwards. This study shows that adolescents and young adults are characterized by a male prevalence, greater T-lineage acute lymphoblastic leuekmia percentage, an increase of poor prognostic molecular markers with aging compared to children, and conclusively quantifies the progressive increase with age of BCR/ABL+ patients, potentially manageable by targeted therapies.
2013
Adult Acute Lymphoblastic Leukemia; Cytogenetics and Molecular Genetics; Immunophenotyping.
01 Pubblicazione su rivista::01a Articolo in rivista
Clinico-biologic features of 5202 acute lymphoblastic leukemia patients enrolled in the Italian AIEOP and GIMEMA Protocols and stratified in age-cohorts / Chiaretti, Sabina; Vitale, A; Cazzaniga, G; Orlando, Sm; Silvestri, D; Fazi, P; Valsecchi, Mg; Elia, Loredana; Testi, Anna Maria; Mancini, Francesca; Conter, V; Te Kronnie, G; Ferrara, F; Di Raimondo, F; Tedeschi, A; Fioritoni, G; Fabbiano, F; Meloni, Giovanna; Specchia, G; Pizzolo, G; Mandelli, Franco; Guarini, Anna; Basso, G; Biondi, A; Foa, Roberto. - In: HAEMATOLOGICA. - ISSN 0390-6078. - 98:11(2013), pp. 1702-1710. [10.3324/haematol.2012.080432]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/521609
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