Current evidence from the available clinical trials strongly support the notion that catheter-based radiofrequency ablation of renal nerves reduces blood pressure and improves blood pressure control in patients with drug-treated resistant hypertension, with data now extending out to 36 months. Accordingly, renal denervation can be considered as a therapeutic option in patients with resistant hypertension, whose blood pressure cannot be controlled by a combination of lifestyle modification and pharmacological therapy according to current guidelines. The fact that renal denervation also reduces whole-bodysympathetic nerve activity suggests that this therapy may also be beneficial in other clinical states characterized by sympathetic nervous system activation-this may ultimately lead to new indications. © The Author 2013.
Expert consensus document from the European Society of Cardiology on catheter-based renal denervation / F., Mahfoud; T. F., Luscher; B., Andersson; I., Baumgartner; R., Cifkova; C., Dimario; P., Doevendans; R., Fagard; J., Fajadet; M., Komajda; T., Lefevre; C., Lotan; H., Sievert; Volpe, Massimo; P., Widimsky; W., Wijns; B., Williams; S., Windecker; A., Witkowski; T., Zeller; M., Bohm. - In: EUROPEAN HEART JOURNAL. - ISSN 0195-668X. - STAMPA. - 34:28(2013), pp. 2149-2157. [10.1093/eurheartj/eht154]
Expert consensus document from the European Society of Cardiology on catheter-based renal denervation
VOLPE, Massimo;
2013
Abstract
Current evidence from the available clinical trials strongly support the notion that catheter-based radiofrequency ablation of renal nerves reduces blood pressure and improves blood pressure control in patients with drug-treated resistant hypertension, with data now extending out to 36 months. Accordingly, renal denervation can be considered as a therapeutic option in patients with resistant hypertension, whose blood pressure cannot be controlled by a combination of lifestyle modification and pharmacological therapy according to current guidelines. The fact that renal denervation also reduces whole-bodysympathetic nerve activity suggests that this therapy may also be beneficial in other clinical states characterized by sympathetic nervous system activation-this may ultimately lead to new indications. © The Author 2013.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
