We report the synthesis and bio-pharmacological evaluation of a class of pyrrole derivatives featuring a small appendage fragment (carbaldehyde, oxime, nitrile) on the central core. Compound 1c proved to be extremely effective in vivo, showing an interesting anti-nociceptic profile that is comparable to reference compounds already marketed, hence representing a great stimulus for a further improvement of this class of molecules.
A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity / Battilocchio, C., Poce, G., Alfonso, S., Porretta, G.C., Consalvi, S., L., S., S., P., A., R., C., G., L., D.C.M., S., S., A., G., L., D.F., P., P., Biava, M.. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 1464-3391. - STAMPA. - (2013), pp. 3695-3701. [10.1016/j.bmc.2013.04.031]
A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity
BATTILOCCHIO, CLAUDIO;POCE, Giovanna;ALFONSO, SALVATORE;PORRETTA, Giulio Cesare;CONSALVI, SARA;BIAVA, Mariangela
2013
Abstract
We report the synthesis and bio-pharmacological evaluation of a class of pyrrole derivatives featuring a small appendage fragment (carbaldehyde, oxime, nitrile) on the central core. Compound 1c proved to be extremely effective in vivo, showing an interesting anti-nociceptic profile that is comparable to reference compounds already marketed, hence representing a great stimulus for a further improvement of this class of molecules.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
