Synaptic transmission is essential for early development of the central nervous system. However, the mechanisms that regulate early synaptic transmission in the cerebral cortex are unclear. PKM zeta is a kinase essential for the maintenance of LTP. We show for the first time that inhibition of PKM zeta produces a profound depression of basal synaptic transmission in neonatal, but not adult, rat perirhinal cortex. This suggests that synapses in early development are in a constitutive LTP-like state. Furthermore, basal synaptic transmission in immature, but not mature, perirhinal cortex relies on persistent activity of metabotropic glutamate (mGlu) receptor, PI3Kinase and mammalian target of rapamycin (mTOR). Thus early in development, cortical synapses exist in an LTP-like state maintained by tonically active mGlu receptor-, mTOR- and PKM zeta- dependent cascades. These results provide new understanding of the molecular mechanisms that control synapses during development and may aid our understanding of developmental disorders such as autism and schizophrenia. This article is part of a Special Issue entitled 'Metabotropic Glutamate Receptors'. (c) 2012 Elsevier Ltd. All rights reserved.

Constitutively active group I mGlu receptors and PKMzeta regulate synaptic transmission in developing perirhinal cortex / Panaccione, Isabella; Rachel, King; Gemma, Molinaro; Barbara, Riozzi; Battaglia, Giuseppe; Nicoletti, Ferdinando; I., Bashir Zafar; Zafar I., Bashir. - In: NEUROPHARMACOLOGY. - ISSN 0028-3908. - 66:(2013), pp. 143-150. [10.1016/j.neuropharm.2012.03.010]

Constitutively active group I mGlu receptors and PKMzeta regulate synaptic transmission in developing perirhinal cortex

PANACCIONE, ISABELLA;BATTAGLIA, Giuseppe;NICOLETTI, Ferdinando;
2013

Abstract

Synaptic transmission is essential for early development of the central nervous system. However, the mechanisms that regulate early synaptic transmission in the cerebral cortex are unclear. PKM zeta is a kinase essential for the maintenance of LTP. We show for the first time that inhibition of PKM zeta produces a profound depression of basal synaptic transmission in neonatal, but not adult, rat perirhinal cortex. This suggests that synapses in early development are in a constitutive LTP-like state. Furthermore, basal synaptic transmission in immature, but not mature, perirhinal cortex relies on persistent activity of metabotropic glutamate (mGlu) receptor, PI3Kinase and mammalian target of rapamycin (mTOR). Thus early in development, cortical synapses exist in an LTP-like state maintained by tonically active mGlu receptor-, mTOR- and PKM zeta- dependent cascades. These results provide new understanding of the molecular mechanisms that control synapses during development and may aid our understanding of developmental disorders such as autism and schizophrenia. This article is part of a Special Issue entitled 'Metabotropic Glutamate Receptors'. (c) 2012 Elsevier Ltd. All rights reserved.
2013
protein translation; development; cerebral cortex; pkmζ; ltp; group i mglu receptor; pkm zeta; mtor
01 Pubblicazione su rivista::01a Articolo in rivista
Constitutively active group I mGlu receptors and PKMzeta regulate synaptic transmission in developing perirhinal cortex / Panaccione, Isabella; Rachel, King; Gemma, Molinaro; Barbara, Riozzi; Battaglia, Giuseppe; Nicoletti, Ferdinando; I., Bashir Zafar; Zafar I., Bashir. - In: NEUROPHARMACOLOGY. - ISSN 0028-3908. - 66:(2013), pp. 143-150. [10.1016/j.neuropharm.2012.03.010]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/516062
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 5
  • Scopus 11
  • ???jsp.display-item.citation.isi??? 9
social impact