QT and Tpeak-Tend (Te) intervals are associated with sudden cardiac death in patients with chronic heart failure (CHF). We studied age-dependent influence on short-term temporal dispersion of these two variables in patients with postischemic CHF. Method: We grouped 75 CHF and 53 healthy control subjects into three age subsets: ≤50 years, >50 years and ≤65 years, and >65 years. We then calculated the following indices: QT and Te variability index (QTVI and TeVI), the ratio between the short-term variability (STV) of QT or Te, and the STV of resting rate (RR) (QT/RR STV and Te/RR STV). Results: In all different age subgroups, patients with CHF showed a higher level of QTVI than age-matched control subjects (≤50 years: P < 0.0001; >50 years and ≤65 years: P < 0.05; >65 years: P <0.05). Patients with CHF < 50 years old also had all repolarization variability indices higher than normal age-matched controls (TeVI, P < 0.05; QT/RR STV, P < 0.05; Te/RR STV, P < 0.05), whereas we did not find any difference between the two older classes of subjects. Both QTVI (r<sup>2</sup>: 0.178, P < 0.05) and TeVI (r<sup>2</sup>: 0.433, P < 0.001) were positively related to age in normal subjects, even if the first correlation was weaker than the second one. Conclusion: Our data showed that QTVI could be used in all ages to evaluate repolarization temporal liability, whereas the other indices are deeply influenced by age. Probably, the age-dependent increase in QTVI was more influenced by a reduction of RR variability reported in older normal subjects. © Piccirillo et al, publisher and licensee Dove Medical Press Ltd.

Influence of aging and chronic heart failure on temporal dispersion of myocardial repolarization / Piccirillo, Gianfranco; Moscucci, Federica; Quaglione, Raffaele; Barilla', Francesco; Magri', Damiano. - In: CLINICAL INTERVENTIONS IN AGING. - ISSN 1178-1998. - ELETTRONICO. - 8:8(2013), pp. 293-300. [10.2147/cia.s41879]

Influence of aging and chronic heart failure on temporal dispersion of myocardial repolarization

PICCIRILLO, Gianfranco;MOSCUCCI , FEDERICA;QUAGLIONE, Raffaele;BARILLA', Francesco;MAGRI', DAMIANO
2013

Abstract

QT and Tpeak-Tend (Te) intervals are associated with sudden cardiac death in patients with chronic heart failure (CHF). We studied age-dependent influence on short-term temporal dispersion of these two variables in patients with postischemic CHF. Method: We grouped 75 CHF and 53 healthy control subjects into three age subsets: ≤50 years, >50 years and ≤65 years, and >65 years. We then calculated the following indices: QT and Te variability index (QTVI and TeVI), the ratio between the short-term variability (STV) of QT or Te, and the STV of resting rate (RR) (QT/RR STV and Te/RR STV). Results: In all different age subgroups, patients with CHF showed a higher level of QTVI than age-matched control subjects (≤50 years: P < 0.0001; >50 years and ≤65 years: P < 0.05; >65 years: P <0.05). Patients with CHF < 50 years old also had all repolarization variability indices higher than normal age-matched controls (TeVI, P < 0.05; QT/RR STV, P < 0.05; Te/RR STV, P < 0.05), whereas we did not find any difference between the two older classes of subjects. Both QTVI (r2: 0.178, P < 0.05) and TeVI (r2: 0.433, P < 0.001) were positively related to age in normal subjects, even if the first correlation was weaker than the second one. Conclusion: Our data showed that QTVI could be used in all ages to evaluate repolarization temporal liability, whereas the other indices are deeply influenced by age. Probably, the age-dependent increase in QTVI was more influenced by a reduction of RR variability reported in older normal subjects. © Piccirillo et al, publisher and licensee Dove Medical Press Ltd.
2013
aging; chronic heart failure; heart rate variability; qt variability; sudden death
01 Pubblicazione su rivista::01a Articolo in rivista
Influence of aging and chronic heart failure on temporal dispersion of myocardial repolarization / Piccirillo, Gianfranco; Moscucci, Federica; Quaglione, Raffaele; Barilla', Francesco; Magri', Damiano. - In: CLINICAL INTERVENTIONS IN AGING. - ISSN 1178-1998. - ELETTRONICO. - 8:8(2013), pp. 293-300. [10.2147/cia.s41879]
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/515862
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 10
  • Scopus 31
  • ???jsp.display-item.citation.isi??? 24
social impact