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TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ∼480 SNPs at the TERT locus in breast (n = 103,991), ovarian (n = 39,774) and BRCA1 mutation carrier (n = 11,705) cancer cases and controls. Leukocyte telomere measurements were also available for 53,724 participants. Most associations cluster into three independent peaks. The minor allele at the peak 1 SNP rs2736108 associates with longer telomeres (P = 5.8 × 10 -7), lower risks for estrogen receptor (ER)-negative (P = 1.0 × 10 -8) and BRCA1 mutation carrier (P = 1.1 × 10 -5) breast cancers and altered promoter assay signal. The minor allele at the peak 2 SNP rs7705526 associates with longer telomeres (P = 2.3 × 10 -14), higher risk of low-malignant-potential ovarian cancer (P = 1.3 × 10 -15) and greater promoter activity. The minor alleles at the peak 3 SNPs rs10069690 and rs2242652 increase ER-negative (P = 1.2 × 10 -12) and BRCA1 mutation carrier (P = 1.6 × 10 -14) breast and invasive ovarian (P = 1.3 × 10 -11) cancer risks but not via altered telomere length. The cancer risk alleles of rs2242652 and rs10069690, respectively, increase silencing and generate a truncated TERT splice variant.

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer / Stig E., Bojesen; Karen A., Pooley; Sharon E., Johnatty; Jonathan, Beesley; Kyriaki, Michailidou; Jonathan P., Tyrer; Stacey L., Edwards; Hilda A., Pickett; Chen Yang, Shen; Chanel E., Smart; Kristine M., Hillman; Phuong L., Mai; Kate, Lawrenson; Michael D., Stutz; Yi, Lu; Rod, Karevan; Nicholas, Woods; Rebecca L., Johnston; Juliet D., French; Xiaoqing, Chen; Maren, Weischer; Sune F., Nielsen; Melanie J., Maranian; Maya, Ghoussaini; Shahana, Ahmed; Caroline, Baynes; Manjeet K., Bolla; Qin, Wang; Joe, Dennis; Lesley, Mcguffog; Daniel, Barrowdale; Andrew, Lee; Catherine S., Healey; Michael, Lush; Daniel C., Tessier; Daniel, Vincent; Françis, Bacot; Ignace, Vergote; Sandrina, Lambrechts; Evelyn, Despierre; Harvey A., Risch; Anna Gonzalez, Neira; Mary Anne, Rossing; Guillermo, Pita; Jennifer A., Doherty; Nuria, Alvarez; Melissa C., Larson; Brooke L., Fridley; Nils, Schoof; Jenny Chang, Claude; Mine S., Cicek; Julian, Peto; Kimberly R., Kalli; Annegien, Broeks; Sebastian M., Armasu; Marjanka K., Schmidt; Linde M., Braaf; Boris, Winterhoff; Heli, Nevanlinna; Gottfried E., Konecny; Diether, Lambrechts; Lisa, Rogmann; Pascal, Guenel; Attila, Teoman; Roger L., Milne; Joaquin J., Garcia; Angela, Cox; Vijayalakshmi, Shridhar; Barbara, Burwinkel; Frederik, Marme; Rebecca, Hein; Elinor J., Sawyer; Christopher A., Haiman; Shan Wang, Gohrke; Irene L., Andrulis; Kirsten B., Moysich; John L., Hopper; Kunle, Odunsi; Annika, Lindblom; Graham G., Giles; Hermann, Brenner; Jacques, Simard; Galina, Lurie; Peter A., Fasching; Michael E., Carney; Paolo, Radice; Lynne R., Wilkens; Anthony, Swerdlow; Marc T., Goodman; Hiltrud, Brauch; Montserrat Garcia, Closas; Peter, Hillemanns; Robert, Winqvist; Matthias, Durst; Peter, Devilee; Ingo, Runnebaum; Anna, Jakubowska; Jan, Lubinski; Arto, Mannermaa; Ralf, Butzow; Natalia V., Bogdanova; Thilo, Dork; Liisa M., Pelttari; Wei, Zheng; Arto, Leminen; Hoda Anton, Culver; Clareann H., Bunker; Vessela, Kristensen; Roberta B., Ness; Kenneth, Muir; Robert, Edwards; Alfons, Meindl; Florian, Heitz; Keitaro, Matsuo; Andreas Du, Bois; Anna H., Wu; Philipp, Harter; Soo Hwang, Teo; Ira, Schwaab; Xiao Ou, Shu; William, Blot; Satoyo, Hosono; Daehee, Kang; Toru, Nakanishi; Mikael, Hartman; Yasushi, Yatabe; Ute, Hamann; Beth Y., Karlan; Suleeporn, Sangrajrang; Susanne Krüger, Kjaer; Valerie, Gaborieau; Allan, Jensen; Diana, Eccles; E., Hogdall; Chen Yang, Shen; Judith, Brown; Yin Ling, Woo; Mitul, Shah; Mat Adenan Noor, Azmi; Robert, Luben; Siti Zawiah, Omar; Kamila, Czene; Robert A., Vierkant; G., Nordestgaard Bo; Henrik, Flyger; Celine, Vachon; Janet E., Olson; Xianshu, Wang; Douglas A., Levine; Anja, Rudolph; Rachel Palmieri, Weber; Dieter Flesch, Janys; Edwin, Iversen; Stefan, Nickels; Joellen M., Schildkraut; Isabel Dos Santos, Silva; Daniel W., Cramer; Lorna, Gibson; Kathryn L., Terry; Olivia, Fletcher; Allison F., Vitonis; C., Ellen Van Der Schoot; Elizabeth M., Poole; Frans B. l., Hogervorst; Shelley S., Tworoger; Jianjun, Liu; Elisa V., Bandera; Jingmei, Li; Sara H., Olson; Keith, Humphreys; Irene, Orlow; Carl, Blomqvist; Lorna Rodriguez, Rodriguez; Kristiina, Aittomaki; Helga B., Salvesen; Taru A., Muranen; Elisabeth, Wik; Barbara, Brouwers; Camilla, Krakstad; Els, Wauters; Mari K., Halle; Hans, Wildiers; Lambertus A., Kiemeney; Claire, Mulot; Katja K., Aben; Pierre Laurent, Puig; Anne Mvan, Altena; Therese, Truong; Leon F. a. g., Massuger; Javier, Benitez; Tanja, Pejovic; Jose Ignacio Arias, Perez; Maureen, Hoatlin; M., Pilar Zamora; Linda S., Cook; Sabapathy P., Balasubramanian; Linda E., Kelemen; Andreas, Schneeweiss; Nhu D., Le; Christof, Sohn; Angela Brooks, Wilson; Ian, Tomlinson; Michael J., Kerin; Nicola, Miller; Cezary, Cybulski; Brian E., Henderson; Janusz, Menkiszak; Fredrick, Schumacher; Nicolas, Wentzensen; Loic Le, Marchand; Hannah P., Yang; Anna Marie, Mulligan; Gord, Glendon; Svend Aage, Engelholm; Julia A., Knight; C. k., Hogdall; Carmel, Apicella; Martin, Gore; Helen, Tsimiklis; Honglin, Song; Melissa C., Southey; Agnes, Jager; A. m. w., Den Ouweland; Robert, Brown; John W. m., Martens; James M., Flanagan; Mieke, Kriege; James, Paul; Sara, Margolin; Nadeem, Siddiqui; Gianluca, Severi; Alice S., Whittemore; Laura, Baglietto; Valerie, Mcguire; Christa, Stegmaier; Weiva, Sieh; Heiko, Muller; Volker, Arndt; France, Labreche; Yu Tang, Gao; Mark S., Goldberg; Gong, Yang; Martine, Dumont; John R., Mclaughlin; Arndt, Hartmann; Arif B., Ekici; Matthias W., Beckmann; Catherine M., Phelan; Michael P., Lux; Jenny Permuth, Wey; Bernard, Peissel; Thomas A., Sellers; Filomena, Ficarazzi; Monica, Barile; Argyrios, Ziogas; Alan, Ashworth; Aleksandra Gentry, Maharaj; Michael, Jones; Susan J., Ramus; Nick, Orr; Usha, Menon; Celeste L., Pearce; Thomas, Bruning; Malcolm C., Pike; Yon Dschun, Ko; Jolanta, Lissowska; Jonine, Figueroa; Jolanta, Kupryjanczyk; Stephen J., Chanock; Agnieszka Dansonka, Mieszkowska; Arja Jukkola, Vuorinen; Iwona K., Rzepecka; Katri, Pylkas; Mariusz, Bidzinski; Saila, Kauppila; Antoinette, Hollestelle; Caroline, Seynaeve; Rob A. e. m., Tollenaar; Katarzyna, Durda; Katarzyna, Jaworska; Jaana M., Hartikainen; Veli Matti, Kosma; Vesa, Kataja; Natalia N., Antonenkova; Jirong, Long; Martha, Shrubsole; Sandra Deming, Halverson; Artitaya, Lophatananon; Pornthep, Siriwanarangsan; Sarah Stewart, Brown; Nina, Ditsch; Peter, Lichtner; Rita K., Schmutzler; Hidemi, Ito; Hiroji, Iwata; Kazuo, Tajima; Chiu Chen, Tseng; Daniel O., Stram; David Van Den, Berg; Cheng Har, Yip; M., Kamran Ikram; Yew Ching, Teh; Hui, Cai; Wei, Lu; Lisa B., Signorello; Qiuyin, Cai; Dong Young, Noh; Keun Young, Yoo; Hui, Miao; Philip Tsau Choong, Iau; Yik Ying, Teo; James, Mckay; Charles, Shapiro; Foluso, Ademuyiwa; George, Fountzilas; Chia Ni, Hsiung; Jyh Cherng, Yu; Ming Feng, Hou; Catherine S., Healey; Craig, Luccarini; Susan, Peock; Dominique Stoppa, Lyonnet; Paolo, Peterlongo; Timothy R., Rebbeck; Marion, Piedmonte; Christian F., Singer; Eitan, Friedman; Mads, Thomassen; Kenneth, Offit; Thomas V. o., Hansen; Susan L., Neuhausen; Csilla I., Szabo; Ignacio, Blanco; Judy, Garber; Steven A., Narod; Jeffrey N., Weitzel; Marco, Montagna; Edith, Olah; Andrew K., Godwin; Drakoulis, Yannoukakos; David E., Goldgar; Trinidad, Caldes; Evgeny N., Imyanitov; Laima, Tihomirova; Banu K., Arun; Ian, Campbell; Arjen R., Mensenkamp; Christi J., Van Asperen; Kees E. p., Van Roozendaal; Hanne Meijers, Heijboer; J., Margriet Collee; Jan C., Oosterwijk; Maartje J., Hooning; Matti A., Rookus; Rob B., Van Der Luijt; T. a. m., Os; D., Gareth Evans; Debra, Frost; Elena, Fineberg; Julian, Barwell; Lisa, Walker; M., John Kennedy; Radka, Platte; Rosemarie, Davidson; Steve D., Ellis; Trevor, Cole; Brigitte Bressac De, Paillerets; Bruno, Buecher; Francesca, Damiola; Laurence, Faivre; Marc, Frenay; Olga M., Sinilnikova; Olivier, Caron; Sophie, Giraud; Sylvie, Mazoyer; Valerie, Bonadona; Virginie Caux, Moncoutier; Aleksandra Toloczko, Grabarek; Jacek, Gronwald; Tomasz, Byrski; Amanda B., Spurdle; Bernardo, Bonanni; Daniela, Zaffaroni; Giannini, Giuseppe; Loris, Bernard; Riccardo, Dolcetti; Siranoush, Manoukian; Norbert, Arnold; Christoph, Engel; Helmut, Deissler; Kerstin, Rhiem; Dieter, Niederacher; Hansjoerg, Plendl; Christian, Sutter; Barbara, Wappenschmidt; Åke, Borg; Beatrice, Melin; Johanna, Rantala; Maria, Soller; Katherine L., Nathanson; Susan M., Domchek; Gustavo C., Rodriguez; Ritu, Salani; Daphne Gschwantler, Kaulich; Muy Kheng, Tea; Shani Shimon, Paluch; Yael, Laitman; Anne Bine, Skytte; Torben A., Kruse; Uffe Birk, Jensen; Mark, Robson; Anne Marie, Gerdes; Bent, Ejlertsen; Lenka, Foretova; Sharon A., Savage; Jenny, Lester; Penny, Soucy; Karoline B., Kuchenbaecker; Curtis, Olswold; Julie M., Cunningham; Susan, Slager; Vernon S., Pankratz; Ed, Dicks; Sunil R., Lakhani; Fergus J., Couch; Per, Hall; Alvaro N. a., Monteiro; Simon A., Gayther; Paul D. p., Pharoah; Roger R., Reddel; Ellen L., Goode; Mark H., Greene; Douglas F., Easton; Andrew, Berchuck; Antonis C., Antoniou; Georgia Chenevix, Trench; Alison M., Dunning. - In: NATURE GENETICS. - ISSN 1061-4036. - STAMPA. - 45:4(2013), pp. 371-384. [10.1038/ng.2566]

Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

GIANNINI, Giuseppe;
2013

Abstract

TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ∼480 SNPs at the TERT locus in breast (n = 103,991), ovarian (n = 39,774) and BRCA1 mutation carrier (n = 11,705) cancer cases and controls. Leukocyte telomere measurements were also available for 53,724 participants. Most associations cluster into three independent peaks. The minor allele at the peak 1 SNP rs2736108 associates with longer telomeres (P = 5.8 × 10 -7), lower risks for estrogen receptor (ER)-negative (P = 1.0 × 10 -8) and BRCA1 mutation carrier (P = 1.1 × 10 -5) breast cancers and altered promoter assay signal. The minor allele at the peak 2 SNP rs7705526 associates with longer telomeres (P = 2.3 × 10 -14), higher risk of low-malignant-potential ovarian cancer (P = 1.3 × 10 -15) and greater promoter activity. The minor alleles at the peak 3 SNPs rs10069690 and rs2242652 increase ER-negative (P = 1.2 × 10 -12) and BRCA1 mutation carrier (P = 1.6 × 10 -14) breast and invasive ovarian (P = 1.3 × 10 -11) cancer risks but not via altered telomere length. The cancer risk alleles of rs2242652 and rs10069690, respectively, increase silencing and generate a truncated TERT splice variant.
2013
tert-clptm1l locus; genome-wide association; genetic-variation; susceptibility loci; buccal cells; fibroblasts; common variants; carcinoma; reverse-transcriptase htert; metaanalysis
01 Pubblicazione su rivista::01a Articolo in rivista
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer / Stig E., Bojesen; Karen A., Pooley; Sharon E., Johnatty; Jonathan, Beesley; Kyriaki, Michailidou; Jonathan P., Tyrer; Stacey L., Edwards; Hilda A., Pickett; Chen Yang, Shen; Chanel E., Smart; Kristine M., Hillman; Phuong L., Mai; Kate, Lawrenson; Michael D., Stutz; Yi, Lu; Rod, Karevan; Nicholas, Woods; Rebecca L., Johnston; Juliet D., French; Xiaoqing, Chen; Maren, Weischer; Sune F., Nielsen; Melanie J., Maranian; Maya, Ghoussaini; Shahana, Ahmed; Caroline, Baynes; Manjeet K., Bolla; Qin, Wang; Joe, Dennis; Lesley, Mcguffog; Daniel, Barrowdale; Andrew, Lee; Catherine S., Healey; Michael, Lush; Daniel C., Tessier; Daniel, Vincent; Françis, Bacot; Ignace, Vergote; Sandrina, Lambrechts; Evelyn, Despierre; Harvey A., Risch; Anna Gonzalez, Neira; Mary Anne, Rossing; Guillermo, Pita; Jennifer A., Doherty; Nuria, Alvarez; Melissa C., Larson; Brooke L., Fridley; Nils, Schoof; Jenny Chang, Claude; Mine S., Cicek; Julian, Peto; Kimberly R., Kalli; Annegien, Broeks; Sebastian M., Armasu; Marjanka K., Schmidt; Linde M., Braaf; Boris, Winterhoff; Heli, Nevanlinna; Gottfried E., Konecny; Diether, Lambrechts; Lisa, Rogmann; Pascal, Guenel; Attila, Teoman; Roger L., Milne; Joaquin J., Garcia; Angela, Cox; Vijayalakshmi, Shridhar; Barbara, Burwinkel; Frederik, Marme; Rebecca, Hein; Elinor J., Sawyer; Christopher A., Haiman; Shan Wang, Gohrke; Irene L., Andrulis; Kirsten B., Moysich; John L., Hopper; Kunle, Odunsi; Annika, Lindblom; Graham G., Giles; Hermann, Brenner; Jacques, Simard; Galina, Lurie; Peter A., Fasching; Michael E., Carney; Paolo, Radice; Lynne R., Wilkens; Anthony, Swerdlow; Marc T., Goodman; Hiltrud, Brauch; Montserrat Garcia, Closas; Peter, Hillemanns; Robert, Winqvist; Matthias, Durst; Peter, Devilee; Ingo, Runnebaum; Anna, Jakubowska; Jan, Lubinski; Arto, Mannermaa; Ralf, Butzow; Natalia V., Bogdanova; Thilo, Dork; Liisa M., Pelttari; Wei, Zheng; Arto, Leminen; Hoda Anton, Culver; Clareann H., Bunker; Vessela, Kristensen; Roberta B., Ness; Kenneth, Muir; Robert, Edwards; Alfons, Meindl; Florian, Heitz; Keitaro, Matsuo; Andreas Du, Bois; Anna H., Wu; Philipp, Harter; Soo Hwang, Teo; Ira, Schwaab; Xiao Ou, Shu; William, Blot; Satoyo, Hosono; Daehee, Kang; Toru, Nakanishi; Mikael, Hartman; Yasushi, Yatabe; Ute, Hamann; Beth Y., Karlan; Suleeporn, Sangrajrang; Susanne Krüger, Kjaer; Valerie, Gaborieau; Allan, Jensen; Diana, Eccles; E., Hogdall; Chen Yang, Shen; Judith, Brown; Yin Ling, Woo; Mitul, Shah; Mat Adenan Noor, Azmi; Robert, Luben; Siti Zawiah, Omar; Kamila, Czene; Robert A., Vierkant; G., Nordestgaard Bo; Henrik, Flyger; Celine, Vachon; Janet E., Olson; Xianshu, Wang; Douglas A., Levine; Anja, Rudolph; Rachel Palmieri, Weber; Dieter Flesch, Janys; Edwin, Iversen; Stefan, Nickels; Joellen M., Schildkraut; Isabel Dos Santos, Silva; Daniel W., Cramer; Lorna, Gibson; Kathryn L., Terry; Olivia, Fletcher; Allison F., Vitonis; C., Ellen Van Der Schoot; Elizabeth M., Poole; Frans B. l., Hogervorst; Shelley S., Tworoger; Jianjun, Liu; Elisa V., Bandera; Jingmei, Li; Sara H., Olson; Keith, Humphreys; Irene, Orlow; Carl, Blomqvist; Lorna Rodriguez, Rodriguez; Kristiina, Aittomaki; Helga B., Salvesen; Taru A., Muranen; Elisabeth, Wik; Barbara, Brouwers; Camilla, Krakstad; Els, Wauters; Mari K., Halle; Hans, Wildiers; Lambertus A., Kiemeney; Claire, Mulot; Katja K., Aben; Pierre Laurent, Puig; Anne Mvan, Altena; Therese, Truong; Leon F. a. g., Massuger; Javier, Benitez; Tanja, Pejovic; Jose Ignacio Arias, Perez; Maureen, Hoatlin; M., Pilar Zamora; Linda S., Cook; Sabapathy P., Balasubramanian; Linda E., Kelemen; Andreas, Schneeweiss; Nhu D., Le; Christof, Sohn; Angela Brooks, Wilson; Ian, Tomlinson; Michael J., Kerin; Nicola, Miller; Cezary, Cybulski; Brian E., Henderson; Janusz, Menkiszak; Fredrick, Schumacher; Nicolas, Wentzensen; Loic Le, Marchand; Hannah P., Yang; Anna Marie, Mulligan; Gord, Glendon; Svend Aage, Engelholm; Julia A., Knight; C. k., Hogdall; Carmel, Apicella; Martin, Gore; Helen, Tsimiklis; Honglin, Song; Melissa C., Southey; Agnes, Jager; A. m. w., Den Ouweland; Robert, Brown; John W. m., Martens; James M., Flanagan; Mieke, Kriege; James, Paul; Sara, Margolin; Nadeem, Siddiqui; Gianluca, Severi; Alice S., Whittemore; Laura, Baglietto; Valerie, Mcguire; Christa, Stegmaier; Weiva, Sieh; Heiko, Muller; Volker, Arndt; France, Labreche; Yu Tang, Gao; Mark S., Goldberg; Gong, Yang; Martine, Dumont; John R., Mclaughlin; Arndt, Hartmann; Arif B., Ekici; Matthias W., Beckmann; Catherine M., Phelan; Michael P., Lux; Jenny Permuth, Wey; Bernard, Peissel; Thomas A., Sellers; Filomena, Ficarazzi; Monica, Barile; Argyrios, Ziogas; Alan, Ashworth; Aleksandra Gentry, Maharaj; Michael, Jones; Susan J., Ramus; Nick, Orr; Usha, Menon; Celeste L., Pearce; Thomas, Bruning; Malcolm C., Pike; Yon Dschun, Ko; Jolanta, Lissowska; Jonine, Figueroa; Jolanta, Kupryjanczyk; Stephen J., Chanock; Agnieszka Dansonka, Mieszkowska; Arja Jukkola, Vuorinen; Iwona K., Rzepecka; Katri, Pylkas; Mariusz, Bidzinski; Saila, Kauppila; Antoinette, Hollestelle; Caroline, Seynaeve; Rob A. e. m., Tollenaar; Katarzyna, Durda; Katarzyna, Jaworska; Jaana M., Hartikainen; Veli Matti, Kosma; Vesa, Kataja; Natalia N., Antonenkova; Jirong, Long; Martha, Shrubsole; Sandra Deming, Halverson; Artitaya, Lophatananon; Pornthep, Siriwanarangsan; Sarah Stewart, Brown; Nina, Ditsch; Peter, Lichtner; Rita K., Schmutzler; Hidemi, Ito; Hiroji, Iwata; Kazuo, Tajima; Chiu Chen, Tseng; Daniel O., Stram; David Van Den, Berg; Cheng Har, Yip; M., Kamran Ikram; Yew Ching, Teh; Hui, Cai; Wei, Lu; Lisa B., Signorello; Qiuyin, Cai; Dong Young, Noh; Keun Young, Yoo; Hui, Miao; Philip Tsau Choong, Iau; Yik Ying, Teo; James, Mckay; Charles, Shapiro; Foluso, Ademuyiwa; George, Fountzilas; Chia Ni, Hsiung; Jyh Cherng, Yu; Ming Feng, Hou; Catherine S., Healey; Craig, Luccarini; Susan, Peock; Dominique Stoppa, Lyonnet; Paolo, Peterlongo; Timothy R., Rebbeck; Marion, Piedmonte; Christian F., Singer; Eitan, Friedman; Mads, Thomassen; Kenneth, Offit; Thomas V. o., Hansen; Susan L., Neuhausen; Csilla I., Szabo; Ignacio, Blanco; Judy, Garber; Steven A., Narod; Jeffrey N., Weitzel; Marco, Montagna; Edith, Olah; Andrew K., Godwin; Drakoulis, Yannoukakos; David E., Goldgar; Trinidad, Caldes; Evgeny N., Imyanitov; Laima, Tihomirova; Banu K., Arun; Ian, Campbell; Arjen R., Mensenkamp; Christi J., Van Asperen; Kees E. p., Van Roozendaal; Hanne Meijers, Heijboer; J., Margriet Collee; Jan C., Oosterwijk; Maartje J., Hooning; Matti A., Rookus; Rob B., Van Der Luijt; T. a. m., Os; D., Gareth Evans; Debra, Frost; Elena, Fineberg; Julian, Barwell; Lisa, Walker; M., John Kennedy; Radka, Platte; Rosemarie, Davidson; Steve D., Ellis; Trevor, Cole; Brigitte Bressac De, Paillerets; Bruno, Buecher; Francesca, Damiola; Laurence, Faivre; Marc, Frenay; Olga M., Sinilnikova; Olivier, Caron; Sophie, Giraud; Sylvie, Mazoyer; Valerie, Bonadona; Virginie Caux, Moncoutier; Aleksandra Toloczko, Grabarek; Jacek, Gronwald; Tomasz, Byrski; Amanda B., Spurdle; Bernardo, Bonanni; Daniela, Zaffaroni; Giannini, Giuseppe; Loris, Bernard; Riccardo, Dolcetti; Siranoush, Manoukian; Norbert, Arnold; Christoph, Engel; Helmut, Deissler; Kerstin, Rhiem; Dieter, Niederacher; Hansjoerg, Plendl; Christian, Sutter; Barbara, Wappenschmidt; Åke, Borg; Beatrice, Melin; Johanna, Rantala; Maria, Soller; Katherine L., Nathanson; Susan M., Domchek; Gustavo C., Rodriguez; Ritu, Salani; Daphne Gschwantler, Kaulich; Muy Kheng, Tea; Shani Shimon, Paluch; Yael, Laitman; Anne Bine, Skytte; Torben A., Kruse; Uffe Birk, Jensen; Mark, Robson; Anne Marie, Gerdes; Bent, Ejlertsen; Lenka, Foretova; Sharon A., Savage; Jenny, Lester; Penny, Soucy; Karoline B., Kuchenbaecker; Curtis, Olswold; Julie M., Cunningham; Susan, Slager; Vernon S., Pankratz; Ed, Dicks; Sunil R., Lakhani; Fergus J., Couch; Per, Hall; Alvaro N. a., Monteiro; Simon A., Gayther; Paul D. p., Pharoah; Roger R., Reddel; Ellen L., Goode; Mark H., Greene; Douglas F., Easton; Andrew, Berchuck; Antonis C., Antoniou; Georgia Chenevix, Trench; Alison M., Dunning. - In: NATURE GENETICS. - ISSN 1061-4036. - STAMPA. - 45:4(2013), pp. 371-384. [10.1038/ng.2566]
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