The upper rim cone tetraguanidinocalix[4]arene 1 is a highly effective catalyst of ATP hydrolysis. The catalytically most active species is the triprotonated form of the catalyst. The three protonated guanidinium groups provide the electrostatic driving force for substrate binding and activation, while the neutral guanidine most likely acts as a nucleophilic catalyst.
ATP cleavage by cone tetraguanidinocalix[4]arene / Salvio, Riccardo; Alessandro, Casnati; Mandolini, Luigi; Francesco, Sansone; Rocco, Ungaro. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - 10:45(2012), pp. 8941-8943. [10.1039/c2ob26688a]
ATP cleavage by cone tetraguanidinocalix[4]arene
SALVIO, RICCARDO;MANDOLINI, Luigi;
2012
Abstract
The upper rim cone tetraguanidinocalix[4]arene 1 is a highly effective catalyst of ATP hydrolysis. The catalytically most active species is the triprotonated form of the catalyst. The three protonated guanidinium groups provide the electrostatic driving force for substrate binding and activation, while the neutral guanidine most likely acts as a nucleophilic catalyst.File allegati a questo prodotto
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