Objectives: Prognosis of comorbid bipolar disorder (BD) and drug abuse is poor. We assessed the efficacy of olanzapine in manic or mixed BD patients, with (SUD) or without (N-SUD) comorbidity with substance use disorder (SUD) and its effect on drug abuse, days of abuse, and craving. Methods: Eighty patients with BD-I (40 SUD) were hospitalized for a manic or mixed episode and received add-on olanzapine. Assessments were conducted at admission, discharge, and 4 and 8 weeks after discharge. Primary outcome was the proportion of responders and remitters in each group. We used a logistic regression model to adjust for possible confounders. We assessed craving and drug-abuse days with a visual analog scale and the Timeline Follow-Back. Results: SUD and N-SUD were similar on response and remission, adjusted for sex, age, years ill, age at first episode, first episode depressive, number of hospitalizations, and duration of hospitalization (odds ratio, 1.09; 95% confidence interval, 1.02-2.29). Mood rating scores dropped significantly from baseline to end point in both groups. Timeline follow-back decreased in SUD from 22.5 to 7.3 at 8 weeks postdischarge, whereas craving dropped from 8.3 to 5.1 (P < 0.03). Conclusions: The effectiveness of short-term olanzapine in BD-I mania or mixed mania did not differ according to SUD comorbidity. Treatment was followed by less substance use/abuse and craving in comorbid bipolar-SUD patients. © 2013 Lippincott Williams & Wilkins.

Effectiveness of short-term olanzapine in patients with bipolar i disorder, with or without comorbidity with substance use disorder / Sani, Gabriele; Kotzalidis, Giorgio; Paul, Vohringer; Pucci, Daniela; Simonetti, Alessio; Giovanni, Manfredi; Savoja, Valeria; Tamorri, STEFANO MARIA; Mazzarini, Lorenzo; Pacchiarotti, Isabella; Telesforo, CARLA LUDOVICA; Ferracuti, Stefano; Brugnoli, Roberto; Ambrosi, Elisa; Caloro, Matteo; DEL CASALE, Antonio; Koukopoulos, Alexia; Derick E., Vergne; Girardi, Paolo; S., Nassir Ghaemi; S., Nassir Ghaemi. - In: JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY. - ISSN 0271-0749. - STAMPA. - 33:2(2013), pp. 231-235. [10.1097/jcp.0b013e318287019c]

Effectiveness of short-term olanzapine in patients with bipolar i disorder, with or without comorbidity with substance use disorder

SANI, Gabriele;KOTZALIDIS, GIORGIO;PUCCI, DANIELA;SIMONETTI, ALESSIO;SAVOJA, Valeria;TAMORRI, STEFANO MARIA;MAZZARINI, LORENZO;PACCHIAROTTI, ISABELLA;TELESFORO, CARLA LUDOVICA;FERRACUTI, Stefano;BRUGNOLI, ROBERTO;AMBROSI, ELISA;CALORO, MATTEO;DEL CASALE, ANTONIO;KOUKOPOULOS, ALEXIA;GIRARDI, Paolo;
2013

Abstract

Objectives: Prognosis of comorbid bipolar disorder (BD) and drug abuse is poor. We assessed the efficacy of olanzapine in manic or mixed BD patients, with (SUD) or without (N-SUD) comorbidity with substance use disorder (SUD) and its effect on drug abuse, days of abuse, and craving. Methods: Eighty patients with BD-I (40 SUD) were hospitalized for a manic or mixed episode and received add-on olanzapine. Assessments were conducted at admission, discharge, and 4 and 8 weeks after discharge. Primary outcome was the proportion of responders and remitters in each group. We used a logistic regression model to adjust for possible confounders. We assessed craving and drug-abuse days with a visual analog scale and the Timeline Follow-Back. Results: SUD and N-SUD were similar on response and remission, adjusted for sex, age, years ill, age at first episode, first episode depressive, number of hospitalizations, and duration of hospitalization (odds ratio, 1.09; 95% confidence interval, 1.02-2.29). Mood rating scores dropped significantly from baseline to end point in both groups. Timeline follow-back decreased in SUD from 22.5 to 7.3 at 8 weeks postdischarge, whereas craving dropped from 8.3 to 5.1 (P < 0.03). Conclusions: The effectiveness of short-term olanzapine in BD-I mania or mixed mania did not differ according to SUD comorbidity. Treatment was followed by less substance use/abuse and craving in comorbid bipolar-SUD patients. © 2013 Lippincott Williams & Wilkins.
2013
comorbidity; olanzapine; bipolar disorder type i; substance use disorder; craving
01 Pubblicazione su rivista::01a Articolo in rivista
Effectiveness of short-term olanzapine in patients with bipolar i disorder, with or without comorbidity with substance use disorder / Sani, Gabriele; Kotzalidis, Giorgio; Paul, Vohringer; Pucci, Daniela; Simonetti, Alessio; Giovanni, Manfredi; Savoja, Valeria; Tamorri, STEFANO MARIA; Mazzarini, Lorenzo; Pacchiarotti, Isabella; Telesforo, CARLA LUDOVICA; Ferracuti, Stefano; Brugnoli, Roberto; Ambrosi, Elisa; Caloro, Matteo; DEL CASALE, Antonio; Koukopoulos, Alexia; Derick E., Vergne; Girardi, Paolo; S., Nassir Ghaemi; S., Nassir Ghaemi. - In: JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY. - ISSN 0271-0749. - STAMPA. - 33:2(2013), pp. 231-235. [10.1097/jcp.0b013e318287019c]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/513275
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