Effect of glucagon in acute experimental liver damage

The authors induced acute liver tissue damage in rats by administration of a massive dose of tetrachloromethane (CCl4) and investigated ultrastructural changes of hepatocytes on the 1st, 2nd, 4th and 7th day after intoxication and the effect of glucagon on the development of ultrastructural changes. CCl4 produced severe destructive changes and dystrophic steatosis of the liver. Gradually, however, the fat dystrophy receded spontaneously and natural regeneration of liver tissue occurred which was apparent from the 4th day onwards. Glucagon administration did not prevent the development of changes after massive intoxication, the changes were, however, slighter. With regard to the short biological half-life of glucagon the authors feel that it is better to administer glucagon in acute liver damage by permanent intravenous infusion in time and in large doses. It would be, however, most effective to administer glucagon by catheter directly into the portal vein.