OBJECTIVE: To measure and assess the significance of myocardial extracellular volume (ECV), determined non-invasively by equilibrium contrast cardiovascular magnetic resonance, as a clinical biomarker in health and a number of cardiac diseases of varying pathophysiology. DESIGN: Prospective study. SETTING: Tertiary referral cardiology centre in London, UK. PATIENTS: 192 patients were mainly recruited from specialist clinics. We studied patients with Anderson-Fabry disease (AFD, n=17), dilated cardiomyopathy (DCM, n=31), hypertrophic cardiomyopathy (HCM, n=31), severe aortic stenosis (AS, n=66), cardiac AL amyloidosis (n=27) and myocardial infarction (MI, n=20). The results were compared with those for 81 normal subjects. RESULTS: In normal subjects, ECV (mean (95% CI), measured in the septum) was slightly higher in women than men (0.273 (0.264 to 0.282 vs 0.233 (0.225 to 0.244), p<0.001), with no change with age. In disease, the ECV of AFD was the same as in normal subjects but higher in all other diseases (p<0.001). Mean ECV was the same in DCM, HCM and AS (0.280, 0.291, 0.276 respectively), but higher in cardiac AL amyloidosis and higher again in MI (0.466 and 0.585 respectively, each p<0.001). Where ECV was elevated, correlations were found with indexed left ventricular mass, end systolic volume, ejection fraction and left atrial area in apparent disease-specific patterns. CONCLUSIONS: Myocardial ECV, assessed non-invasively in the septum with equilibrium contrast cardiovascular magnetic resonance, shows gender differences in normal individuals and disease-specific variability. Therefore, ECV shows early potential to be a useful biomarker in health and disease.

Cardiovascular magnetic resonance measurement of myocardial extracellular volume in health and disease / Sado, Dm; Flett, As; Banypersad, Sm; White, Sk; Maestrini, Viviana; Quarta, G.; Lachman, Rh; Murphy, E; Mehta, A; Hughes, Da; Mckenna, Wj; Taylor, Am; Hausenloy, Dj; Hawkins, Pn; Elliott, Pm; Moon, J. C.. - In: HEART. - ISSN 1355-6037. - ELETTRONICO. - 98:19(2012), pp. 1436-1441. [10.1136/heartjnl-2012-302346]

Cardiovascular magnetic resonance measurement of myocardial extracellular volume in health and disease

MAESTRINI, VIVIANA;
2012

Abstract

OBJECTIVE: To measure and assess the significance of myocardial extracellular volume (ECV), determined non-invasively by equilibrium contrast cardiovascular magnetic resonance, as a clinical biomarker in health and a number of cardiac diseases of varying pathophysiology. DESIGN: Prospective study. SETTING: Tertiary referral cardiology centre in London, UK. PATIENTS: 192 patients were mainly recruited from specialist clinics. We studied patients with Anderson-Fabry disease (AFD, n=17), dilated cardiomyopathy (DCM, n=31), hypertrophic cardiomyopathy (HCM, n=31), severe aortic stenosis (AS, n=66), cardiac AL amyloidosis (n=27) and myocardial infarction (MI, n=20). The results were compared with those for 81 normal subjects. RESULTS: In normal subjects, ECV (mean (95% CI), measured in the septum) was slightly higher in women than men (0.273 (0.264 to 0.282 vs 0.233 (0.225 to 0.244), p<0.001), with no change with age. In disease, the ECV of AFD was the same as in normal subjects but higher in all other diseases (p<0.001). Mean ECV was the same in DCM, HCM and AS (0.280, 0.291, 0.276 respectively), but higher in cardiac AL amyloidosis and higher again in MI (0.466 and 0.585 respectively, each p<0.001). Where ECV was elevated, correlations were found with indexed left ventricular mass, end systolic volume, ejection fraction and left atrial area in apparent disease-specific patterns. CONCLUSIONS: Myocardial ECV, assessed non-invasively in the septum with equilibrium contrast cardiovascular magnetic resonance, shows gender differences in normal individuals and disease-specific variability. Therefore, ECV shows early potential to be a useful biomarker in health and disease.
2012
ECV; T1 mapping; normal range; health
01 Pubblicazione su rivista::01a Articolo in rivista
Cardiovascular magnetic resonance measurement of myocardial extracellular volume in health and disease / Sado, Dm; Flett, As; Banypersad, Sm; White, Sk; Maestrini, Viviana; Quarta, G.; Lachman, Rh; Murphy, E; Mehta, A; Hughes, Da; Mckenna, Wj; Taylor, Am; Hausenloy, Dj; Hawkins, Pn; Elliott, Pm; Moon, J. C.. - In: HEART. - ISSN 1355-6037. - ELETTRONICO. - 98:19(2012), pp. 1436-1441. [10.1136/heartjnl-2012-302346]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/512594
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