White matter hyperintensities contribute to the presentation of AD and, in the context of significant amyloid deposition, may provide a second hit necessary for the clinical manifestation of the disease. As risk factors for the development of WMHs are modifiable, these findings suggest intervention and prevention strategies for the clinical syndrome of AD.

White matter hyperintensities and cerebral amyloidosis: necessary and sufficient for clinical expression of Alzheimer disease? / Provenzano, Fa; Muraskin, J; Tosto, Giuseppe; Narkhede, A; Wasserman, Bt; Griffith, Ey; Guzman, Va; Meier, Ib; Zimmerman, Me; Brickman, Am. - In: JAMA NEUROLOGY. - ISSN 2168-6149. - (2013), pp. ...-....

White matter hyperintensities and cerebral amyloidosis: necessary and sufficient for clinical expression of Alzheimer disease?

TOSTO, GIUSEPPE;
2013

Abstract

White matter hyperintensities contribute to the presentation of AD and, in the context of significant amyloid deposition, may provide a second hit necessary for the clinical manifestation of the disease. As risk factors for the development of WMHs are modifiable, these findings suggest intervention and prevention strategies for the clinical syndrome of AD.
2013
Alzheimer; white matter hyperintensities; amyloidosis
01 Pubblicazione su rivista::01a Articolo in rivista
White matter hyperintensities and cerebral amyloidosis: necessary and sufficient for clinical expression of Alzheimer disease? / Provenzano, Fa; Muraskin, J; Tosto, Giuseppe; Narkhede, A; Wasserman, Bt; Griffith, Ey; Guzman, Va; Meier, Ib; Zimmerman, Me; Brickman, Am. - In: JAMA NEUROLOGY. - ISSN 2168-6149. - (2013), pp. ...-....
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/510795
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