Free NH 2-substituted 3-arylindoles have been prepared usually in good to high yields through the palladium-catalyzed reaction of readily available 2-alkynyltrifluoroacetanilides with arylboronic acids under oxidative conditions. The reaction tolerates a variety of useful functional groups both in the arylboronic acid and in the alkyne, including chloro, formyl, and ester groups. © 2013 The Royal Society of Chemistry.
2-Substituted 3-arylindoles through palladium-catalyzed arylative cyclization of 2-alkynyltrifluoroacetanilides with arylboronic acids under oxidative conditions / Antonio, Arcadi; Cacchi, Sandro; Fabrizi, Giancarlo; Goggiamani, Antonella; Iazzetti, Antonia; Fabio, Marinelli. - In: ORGANIC & BIOMOLECULAR CHEMISTRY. - ISSN 1477-0520. - 11:4(2013), pp. 545-548. [10.1039/c2ob27125g]
2-Substituted 3-arylindoles through palladium-catalyzed arylative cyclization of 2-alkynyltrifluoroacetanilides with arylboronic acids under oxidative conditions
CACCHI, Sandro;FABRIZI, Giancarlo;GOGGIAMANI, ANTONELLA;IAZZETTI, Antonia;
2013
Abstract
Free NH 2-substituted 3-arylindoles have been prepared usually in good to high yields through the palladium-catalyzed reaction of readily available 2-alkynyltrifluoroacetanilides with arylboronic acids under oxidative conditions. The reaction tolerates a variety of useful functional groups both in the arylboronic acid and in the alkyne, including chloro, formyl, and ester groups. © 2013 The Royal Society of Chemistry.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
